The regulatory role of dendritic cells in the immune response

Francesca Granucci, Ivan Zanoni, Sonia Feau, Giusy Capuano, Paola Ricciardi-Castagnoli

Research output: Contribution to journalArticle

Abstract

Dendritic cells (DCs) are key regulators of immune reactions. They control early innate responses, regulate longlasting adaptive immunity and contribute to the maintenance of self-tolerance. DCs continuously monitor the environment through a multifaceted innate antigen receptor repertoire and, in response to perturbations, start a complex genetic reprogramming that leads to a complete activation of innate and, then, adaptive immune responses. This review discusses how DCs become efficient activators of NK and, subsequently, T cells following a microbial encounter.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume134
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

Dendritic Cells
Adaptive Immunity
Self Tolerance
Antigen Receptors
T-Lymphocytes

Keywords

  • Cytoskeleton
  • Dendritic cells
  • Immune response, adaptive
  • Immune response, innate
  • Interleukin-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Granucci, F., Zanoni, I., Feau, S., Capuano, G., & Ricciardi-Castagnoli, P. (2004). The regulatory role of dendritic cells in the immune response. International Archives of Allergy and Immunology, 134(3), 179-185. https://doi.org/10.1159/000078764

The regulatory role of dendritic cells in the immune response. / Granucci, Francesca; Zanoni, Ivan; Feau, Sonia; Capuano, Giusy; Ricciardi-Castagnoli, Paola.

In: International Archives of Allergy and Immunology, Vol. 134, No. 3, 2004, p. 179-185.

Research output: Contribution to journalArticle

Granucci, F, Zanoni, I, Feau, S, Capuano, G & Ricciardi-Castagnoli, P 2004, 'The regulatory role of dendritic cells in the immune response', International Archives of Allergy and Immunology, vol. 134, no. 3, pp. 179-185. https://doi.org/10.1159/000078764
Granucci, Francesca ; Zanoni, Ivan ; Feau, Sonia ; Capuano, Giusy ; Ricciardi-Castagnoli, Paola. / The regulatory role of dendritic cells in the immune response. In: International Archives of Allergy and Immunology. 2004 ; Vol. 134, No. 3. pp. 179-185.
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