Abstract
Dendritic cells (DCs) are key regulators of immune reactions. They control early innate responses, regulate longlasting adaptive immunity and contribute to the maintenance of self-tolerance. DCs continuously monitor the environment through a multifaceted innate antigen receptor repertoire and, in response to perturbations, start a complex genetic reprogramming that leads to a complete activation of innate and, then, adaptive immune responses. This review discusses how DCs become efficient activators of NK and, subsequently, T cells following a microbial encounter.
| Original language | English |
|---|---|
| Pages (from-to) | 179-185 |
| Number of pages | 7 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 134 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2004 |
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Keywords
- Cytoskeleton
- Dendritic cells
- Immune response, adaptive
- Immune response, innate
- Interleukin-2
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
The regulatory role of dendritic cells in the immune response. / Granucci, Francesca; Zanoni, Ivan; Feau, Sonia; Capuano, Giusy; Ricciardi-Castagnoli, Paola.
In: International Archives of Allergy and Immunology, Vol. 134, No. 3, 2004, p. 179-185.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The regulatory role of dendritic cells in the immune response
AU - Granucci, Francesca
AU - Zanoni, Ivan
AU - Feau, Sonia
AU - Capuano, Giusy
AU - Ricciardi-Castagnoli, Paola
PY - 2004
Y1 - 2004
N2 - Dendritic cells (DCs) are key regulators of immune reactions. They control early innate responses, regulate longlasting adaptive immunity and contribute to the maintenance of self-tolerance. DCs continuously monitor the environment through a multifaceted innate antigen receptor repertoire and, in response to perturbations, start a complex genetic reprogramming that leads to a complete activation of innate and, then, adaptive immune responses. This review discusses how DCs become efficient activators of NK and, subsequently, T cells following a microbial encounter.
AB - Dendritic cells (DCs) are key regulators of immune reactions. They control early innate responses, regulate longlasting adaptive immunity and contribute to the maintenance of self-tolerance. DCs continuously monitor the environment through a multifaceted innate antigen receptor repertoire and, in response to perturbations, start a complex genetic reprogramming that leads to a complete activation of innate and, then, adaptive immune responses. This review discusses how DCs become efficient activators of NK and, subsequently, T cells following a microbial encounter.
KW - Cytoskeleton
KW - Dendritic cells
KW - Immune response, adaptive
KW - Immune response, innate
KW - Interleukin-2
UR - http://www.scopus.com/inward/record.url?scp=3042625962&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=3042625962&partnerID=8YFLogxK
U2 - 10.1159/000078764
DO - 10.1159/000078764
M3 - Article
C2 - 15178886
AN - SCOPUS:3042625962
VL - 134
SP - 179
EP - 185
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 3
ER -