The regulatory role of dendritic cells in the immune response

Francesca Granucci, Ivan Zanoni, Sonia Feau, Giusy Capuano, Paola Ricciardi-Castagnoli

Research output: Contribution to journalArticlepeer-review

Abstract

Dendritic cells (DCs) are key regulators of immune reactions. They control early innate responses, regulate longlasting adaptive immunity and contribute to the maintenance of self-tolerance. DCs continuously monitor the environment through a multifaceted innate antigen receptor repertoire and, in response to perturbations, start a complex genetic reprogramming that leads to a complete activation of innate and, then, adaptive immune responses. This review discusses how DCs become efficient activators of NK and, subsequently, T cells following a microbial encounter.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalInternational Archives of Allergy and Immunology
Volume134
Issue number3
DOIs
Publication statusPublished - 2004

Keywords

  • Cytoskeleton
  • Dendritic cells
  • Immune response, adaptive
  • Immune response, innate
  • Interleukin-2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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