Abstract
Dendritic cells (DCs) are key regulators of immune reactions. They control early innate responses, regulate longlasting adaptive immunity and contribute to the maintenance of self-tolerance. DCs continuously monitor the environment through a multifaceted innate antigen receptor repertoire and, in response to perturbations, start a complex genetic reprogramming that leads to a complete activation of innate and, then, adaptive immune responses. This review discusses how DCs become efficient activators of NK and, subsequently, T cells following a microbial encounter.
Original language | English |
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Pages (from-to) | 179-185 |
Number of pages | 7 |
Journal | International Archives of Allergy and Immunology |
Volume | 134 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2004 |
Keywords
- Cytoskeleton
- Dendritic cells
- Immune response, adaptive
- Immune response, innate
- Interleukin-2
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology