The Regulatory Role of the Human Mediodorsal Thalamus

Giulio Pergola, Lola Danet, Anne Lise Pitel, Giovanni A. Carlesimo, Shailendra Segobin, Jérémie Pariente, Boris Suchan, Anna S. Mitchell, Emmanuel J. Barbeau

Research output: Contribution to journalArticlepeer-review


The function of the human mediodorsal thalamic nucleus (MD) has so far eluded a clear definition in terms of specific cognitive processes and tasks. Although it was at first proposed to play a role in long-term memory, a set of recent studies in animals and humans has revealed a more complex, and broader, role in several cognitive functions. The MD seems to play a multifaceted role in higher cognitive functions together with the prefrontal cortex and other cortical and subcortical brain areas. Specifically, we propose that the MD is involved in the regulation of cortical networks especially when the maintenance and temporal extension of persistent activity patterns in the frontal lobe areas are required.

Original languageEnglish
JournalTrends in Cognitive Sciences
Publication statusAccepted/In press - Jan 1 2018


  • mediodorsal thalamus
  • memory
  • neuroimaging
  • persistent activity
  • prefrontal cortex
  • temporal extension

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


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