The relation between MRI measures of inflammation and neurodegeneration in multiple sclerosis

Matilde Inglese, Beatrice Benedetti, Massimo Filippi

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Gadolinium-enhanced magnetic resonance imaging (MRI) and measures of brain volume have been extensively applied in large-scale studies to assess disease activity and irreversible tissue damage in multiple sclerosis (MS). Although histopathological studies of MS demonstrated that axonal transection occurs at sites of inflammatory changes, the correlation between brain tissue loss and gadolinium enhancement was found to be either absent or poor in virtually all in vivo MRI studies. This review discusses the reasons of this "inflammation/neurodegeneration mismatch" in MS and proposes possible strategies for a better in vivo characterization of the complex pathological process of this disease.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalJournal of the Neurological Sciences
Volume233
Issue number1-2
DOIs
Publication statusPublished - Jun 15 2005

Fingerprint

Multiple Sclerosis
Magnetic Resonance Imaging
Gadolinium
Inflammation
Brain
Pathologic Processes

Keywords

  • Inflammation
  • Magnetic resonance imaging
  • Multiple sclerosis
  • Neurodegeneration

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

The relation between MRI measures of inflammation and neurodegeneration in multiple sclerosis. / Inglese, Matilde; Benedetti, Beatrice; Filippi, Massimo.

In: Journal of the Neurological Sciences, Vol. 233, No. 1-2, 15.06.2005, p. 15-19.

Research output: Contribution to journalArticle

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