The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure

Paolo Marzullo; Barbara Verti; Giulio Savia; Gillian E. Walker; Gabriele Guzzaloni; Mariantonella Tagliaferri; Annamaria Di Blasio; Antonio Liuzzi

doi:10.1210/jc.2003-031328

The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure

Paolo Marzullo, Barbara Verti, Giulio Savia, Gillian E. Walker, Gabriele Guzzaloni, Mariantonella Tagliaferri, Annamaria Di Blasio, Antonio Liuzzi

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

Ghrelin is a gastric hormone that exerts a stimulatory effect on appetite and fat accumulation. Ser(3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although des-octanoylated forms may retain biological functions in vitro. Circulating ghrelin levels are usually low in obesity and in states of positive energy balance. Hence, the aim of our study was to analyze plasma active and serum total ghrelin levels in 20 obese (ages, 22-42 yr; body mass index, 41.3 ± 1.1 kg/m²) and 20 lean subjects (ages, 22-43 yr; body mass index, 22.4 ± 0.6 kg/m²) as well as their relationship to measures of glucose homeostasis, body fat, and resting energy expenditure (REE). The measured/predicted REE percentage ratio was calculated to subdivide groups into those with positive (≥100%) and negative (

Original language	English
Pages (from-to)	936-939
Number of pages	4
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	89
Issue number	2
DOIs	https://doi.org/10.1210/jc.2003-031328
Publication status	Published - Feb 2004

ASJC Scopus subject areas

Biochemistry
Endocrinology, Diabetes and Metabolism

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The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure. / Marzullo, Paolo; Verti, Barbara; Savia, Giulio; Walker, Gillian E.; Guzzaloni, Gabriele; Tagliaferri, Mariantonella; Di Blasio, Annamaria; Liuzzi, Antonio.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 2, 02.2004, p. 936-939.

Research output: Contribution to journal › Article › peer-review

Marzullo, Paolo ; Verti, Barbara ; Savia, Giulio ; Walker, Gillian E. ; Guzzaloni, Gabriele ; Tagliaferri, Mariantonella ; Di Blasio, Annamaria ; Liuzzi, Antonio. / The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure. In: Journal of Clinical Endocrinology and Metabolism. 2004 ; Vol. 89, No. 2. pp. 936-939.

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