Abstract
Ghrelin is a gastric hormone that exerts a stimulatory effect on appetite and fat accumulation. Ser(3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although des-octanoylated forms may retain biological functions in vitro. Circulating ghrelin levels are usually low in obesity and in states of positive energy balance. Hence, the aim of our study was to analyze plasma active and serum total ghrelin levels in 20 obese (ages, 22-42 yr; body mass index, 41.3 ± 1.1 kg/m2) and 20 lean subjects (ages, 22-43 yr; body mass index, 22.4 ± 0.6 kg/m2) as well as their relationship to measures of glucose homeostasis, body fat, and resting energy expenditure (REE). The measured/predicted REE percentage ratio was calculated to subdivide groups into those with positive (≥100%) and negative (
| Original language | English |
|---|---|
| Pages (from-to) | 936-939 |
| Number of pages | 4 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 89 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2004 |
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ASJC Scopus subject areas
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure. / Marzullo, Paolo; Verti, Barbara; Savia, Giulio; Walker, Gillian E.; Guzzaloni, Gabriele; Tagliaferri, Mariantonella; Di Blasio, Annamaria; Liuzzi, Antonio.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 89, No. 2, 02.2004, p. 936-939.Research output: Contribution to journal › Article
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TY - JOUR
T1 - The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure
AU - Marzullo, Paolo
AU - Verti, Barbara
AU - Savia, Giulio
AU - Walker, Gillian E.
AU - Guzzaloni, Gabriele
AU - Tagliaferri, Mariantonella
AU - Di Blasio, Annamaria
AU - Liuzzi, Antonio
PY - 2004/2
Y1 - 2004/2
N2 - Ghrelin is a gastric hormone that exerts a stimulatory effect on appetite and fat accumulation. Ser(3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although des-octanoylated forms may retain biological functions in vitro. Circulating ghrelin levels are usually low in obesity and in states of positive energy balance. Hence, the aim of our study was to analyze plasma active and serum total ghrelin levels in 20 obese (ages, 22-42 yr; body mass index, 41.3 ± 1.1 kg/m2) and 20 lean subjects (ages, 22-43 yr; body mass index, 22.4 ± 0.6 kg/m2) as well as their relationship to measures of glucose homeostasis, body fat, and resting energy expenditure (REE). The measured/predicted REE percentage ratio was calculated to subdivide groups into those with positive (≥100%) and negative (
AB - Ghrelin is a gastric hormone that exerts a stimulatory effect on appetite and fat accumulation. Ser(3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although des-octanoylated forms may retain biological functions in vitro. Circulating ghrelin levels are usually low in obesity and in states of positive energy balance. Hence, the aim of our study was to analyze plasma active and serum total ghrelin levels in 20 obese (ages, 22-42 yr; body mass index, 41.3 ± 1.1 kg/m2) and 20 lean subjects (ages, 22-43 yr; body mass index, 22.4 ± 0.6 kg/m2) as well as their relationship to measures of glucose homeostasis, body fat, and resting energy expenditure (REE). The measured/predicted REE percentage ratio was calculated to subdivide groups into those with positive (≥100%) and negative (
UR - http://www.scopus.com/inward/record.url?scp=1442303291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1442303291&partnerID=8YFLogxK
U2 - 10.1210/jc.2003-031328
DO - 10.1210/jc.2003-031328
M3 - Article
C2 - 14764817
AN - SCOPUS:1442303291
VL - 89
SP - 936
EP - 939
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 2
ER -