The Relationship between Active Ghrelin Levels and Human Obesity Involves Alterations in Resting Energy Expenditure

Paolo Marzullo, Barbara Verti, Giulio Savia, Gillian E. Walker, Gabriele Guzzaloni, Mariantonella Tagliaferri, Annamaria Di Blasio, Antonio Liuzzi

Research output: Contribution to journalArticlepeer-review

Abstract

Ghrelin is a gastric hormone that exerts a stimulatory effect on appetite and fat accumulation. Ser(3) octanoylation is regarded as a prerequisite for ghrelin biological activity, although des-octanoylated forms may retain biological functions in vitro. Circulating ghrelin levels are usually low in obesity and in states of positive energy balance. Hence, the aim of our study was to analyze plasma active and serum total ghrelin levels in 20 obese (ages, 22-42 yr; body mass index, 41.3 ± 1.1 kg/m2) and 20 lean subjects (ages, 22-43 yr; body mass index, 22.4 ± 0.6 kg/m2) as well as their relationship to measures of glucose homeostasis, body fat, and resting energy expenditure (REE). The measured/predicted REE percentage ratio was calculated to subdivide groups into those with positive (≥100%) and negative (

Original languageEnglish
Pages (from-to)936-939
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume89
Issue number2
DOIs
Publication statusPublished - Feb 2004

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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