Abstract
Lower limb muscle chronic hyperactivity in hereditary spastic paraplegia (HSP) is the consequence of motor corticospinal tract involvement, which in turn has been hypothesized to be of mitochondrial origin. In order to assess skeletal muscle aerobic metabolism and sympathetic response during exercise in 10 HSP patients, we evaluated their blood lactate and catecholamine levels during an incremental workload bicycle exercise. Lactate, but not epinephrine or norepinephrine, levels were significantly higher in the HSP patients than in control subjects, in both resting conditions and during exercise. In the patients, the anaerobic lactate threshold was reached prematurely (at 50% of the predicted normal maximal power output) when compared to normal controls. This finding was not related to any specific muscle morphology or histochemical activity. Although other factors, including chronic spasticity and muscle deconditioning, have to be considered in the interpretation of our data, our results suggest the possible involvement of a mitochondrial mechanism, independently of sympathetic system overactivation, in exercising skeletal muscle of HSP patients.
| Original language | English |
|---|---|
| Pages (from-to) | 83-87 |
| Number of pages | 5 |
| Journal | Functional Neurology |
| Volume | 18 |
| Issue number | 2 |
| Publication status | Published - Apr 2003 |
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Keywords
- Catecholamines
- Exercise test
- Hereditary spastic paraparesis
- Lactate
- Mitochondria
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
The relationship between anaerobic lactate threshold and plasma catecholamines during incremental exercise in hereditary spastic paraplegia. / Siciliano, Gabriele; Pasquali, Livia; Manca, Maria Laura; Del Corona, Alberto; Tessa, Alessandra; Patrono, Clarice; Prontera, Concetta; Zucchelli, Giancarlo; Santorelli, Filippo M.
In: Functional Neurology, Vol. 18, No. 2, 04.2003, p. 83-87.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relationship between anaerobic lactate threshold and plasma catecholamines during incremental exercise in hereditary spastic paraplegia
AU - Siciliano, Gabriele
AU - Pasquali, Livia
AU - Manca, Maria Laura
AU - Del Corona, Alberto
AU - Tessa, Alessandra
AU - Patrono, Clarice
AU - Prontera, Concetta
AU - Zucchelli, Giancarlo
AU - Santorelli, Filippo M.
PY - 2003/4
Y1 - 2003/4
N2 - Lower limb muscle chronic hyperactivity in hereditary spastic paraplegia (HSP) is the consequence of motor corticospinal tract involvement, which in turn has been hypothesized to be of mitochondrial origin. In order to assess skeletal muscle aerobic metabolism and sympathetic response during exercise in 10 HSP patients, we evaluated their blood lactate and catecholamine levels during an incremental workload bicycle exercise. Lactate, but not epinephrine or norepinephrine, levels were significantly higher in the HSP patients than in control subjects, in both resting conditions and during exercise. In the patients, the anaerobic lactate threshold was reached prematurely (at 50% of the predicted normal maximal power output) when compared to normal controls. This finding was not related to any specific muscle morphology or histochemical activity. Although other factors, including chronic spasticity and muscle deconditioning, have to be considered in the interpretation of our data, our results suggest the possible involvement of a mitochondrial mechanism, independently of sympathetic system overactivation, in exercising skeletal muscle of HSP patients.
AB - Lower limb muscle chronic hyperactivity in hereditary spastic paraplegia (HSP) is the consequence of motor corticospinal tract involvement, which in turn has been hypothesized to be of mitochondrial origin. In order to assess skeletal muscle aerobic metabolism and sympathetic response during exercise in 10 HSP patients, we evaluated their blood lactate and catecholamine levels during an incremental workload bicycle exercise. Lactate, but not epinephrine or norepinephrine, levels were significantly higher in the HSP patients than in control subjects, in both resting conditions and during exercise. In the patients, the anaerobic lactate threshold was reached prematurely (at 50% of the predicted normal maximal power output) when compared to normal controls. This finding was not related to any specific muscle morphology or histochemical activity. Although other factors, including chronic spasticity and muscle deconditioning, have to be considered in the interpretation of our data, our results suggest the possible involvement of a mitochondrial mechanism, independently of sympathetic system overactivation, in exercising skeletal muscle of HSP patients.
KW - Catecholamines
KW - Exercise test
KW - Hereditary spastic paraparesis
KW - Lactate
KW - Mitochondria
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UR - http://www.scopus.com/inward/citedby.url?scp=0041869614&partnerID=8YFLogxK
M3 - Article
VL - 18
SP - 83
EP - 87
JO - Functional Neurology
JF - Functional Neurology
SN - 0393-5264
IS - 2
ER -