The relationship between blood pressure variability, obesity and left atrial phasic function in hypertensive population

Marijana Tadic, Cesare Cuspidi, Irena Ilic, Jelena Suzic-Lazić, Vladimir Zivanovic, Ljilja Jozika, Vera Celic

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We sought to investigate the relationship between blood pressure (BP) variability and left atrial (LA) phasic function assessed by volumetric and speckle tracking method in normal-weight, overweight and obese hypertensive patients. This cross-sectional study included 164 untreated hypertensive subjects who underwent a 24-h ambulatory BP monitoring and complete two-dimensional echocardiographic examination (2DE). All the patients were separated into three groups according to their body mass index (BMI): normal-weight patients (BMI <25 kg/m2), overweight patients (25 ≤ BMI <30 kg/m2), and obese patients (BMI ≥ 30 kg/m2). Daytime, nighttime and 24 h BP variability indices were higher in obese hypertensive subjects than in lean patients. Maximum and minimum LA volumes and volume indexes gradually and significantly increased, whereas pre-A LAV decreased, from normal-weight to obese subjects. Total and passive LA emptying fractions, representing LA reservoir and conduit function, gradually reduced from lean to obese individuals. Active LA EF, the parameter of LA booster pump function, increased in the same direction. Similar results were obtained by 2DE strain analysis. BP variability parameters were associated with structural, functional and mechanical parameters of LA remodeling in the whole study population. The parameters of LA reservoir function were negatively related with BP variability indices, whereas the parameters of LA pump function were positively related with BP variability indices. Obesity significantly impacts BP variability and LA phasic function in untreated hypertensive subjects. BP variability is associated with LA remodeling independent of BP, left ventricular systolic and diastolic function.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalInternational Journal of Cardiovascular Imaging
DOIs
Publication statusAccepted/In press - Dec 12 2015

Fingerprint

Left Atrial Function
Obesity
Blood Pressure
Population
Body Mass Index
Atrial Remodeling
Weights and Measures
Ambulatory Blood Pressure Monitoring
Cross-Sectional Studies

Keywords

  • Hypertension
  • Left atrium
  • Obesity
  • Overweight
  • Two-dimensional strain

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

The relationship between blood pressure variability, obesity and left atrial phasic function in hypertensive population. / Tadic, Marijana; Cuspidi, Cesare; Ilic, Irena; Suzic-Lazić, Jelena; Zivanovic, Vladimir; Jozika, Ljilja; Celic, Vera.

In: International Journal of Cardiovascular Imaging, 12.12.2015, p. 1-10.

Research output: Contribution to journalArticle

Tadic, Marijana ; Cuspidi, Cesare ; Ilic, Irena ; Suzic-Lazić, Jelena ; Zivanovic, Vladimir ; Jozika, Ljilja ; Celic, Vera. / The relationship between blood pressure variability, obesity and left atrial phasic function in hypertensive population. In: International Journal of Cardiovascular Imaging. 2015 ; pp. 1-10.
@article{31fc6f18f64a4069920141b7df950327,
title = "The relationship between blood pressure variability, obesity and left atrial phasic function in hypertensive population",
abstract = "We sought to investigate the relationship between blood pressure (BP) variability and left atrial (LA) phasic function assessed by volumetric and speckle tracking method in normal-weight, overweight and obese hypertensive patients. This cross-sectional study included 164 untreated hypertensive subjects who underwent a 24-h ambulatory BP monitoring and complete two-dimensional echocardiographic examination (2DE). All the patients were separated into three groups according to their body mass index (BMI): normal-weight patients (BMI <25 kg/m2), overweight patients (25 ≤ BMI <30 kg/m2), and obese patients (BMI ≥ 30 kg/m2). Daytime, nighttime and 24 h BP variability indices were higher in obese hypertensive subjects than in lean patients. Maximum and minimum LA volumes and volume indexes gradually and significantly increased, whereas pre-A LAV decreased, from normal-weight to obese subjects. Total and passive LA emptying fractions, representing LA reservoir and conduit function, gradually reduced from lean to obese individuals. Active LA EF, the parameter of LA booster pump function, increased in the same direction. Similar results were obtained by 2DE strain analysis. BP variability parameters were associated with structural, functional and mechanical parameters of LA remodeling in the whole study population. The parameters of LA reservoir function were negatively related with BP variability indices, whereas the parameters of LA pump function were positively related with BP variability indices. Obesity significantly impacts BP variability and LA phasic function in untreated hypertensive subjects. BP variability is associated with LA remodeling independent of BP, left ventricular systolic and diastolic function.",
keywords = "Hypertension, Left atrium, Obesity, Overweight, Two-dimensional strain",
author = "Marijana Tadic and Cesare Cuspidi and Irena Ilic and Jelena Suzic-Lazić and Vladimir Zivanovic and Ljilja Jozika and Vera Celic",
year = "2015",
month = "12",
day = "12",
doi = "10.1007/s10554-015-0822-8",
language = "English",
pages = "1--10",
journal = "International Journal of Cardiovascular Imaging",
issn = "1569-5794",
publisher = "Springer Netherlands",

}

TY - JOUR

T1 - The relationship between blood pressure variability, obesity and left atrial phasic function in hypertensive population

AU - Tadic, Marijana

AU - Cuspidi, Cesare

AU - Ilic, Irena

AU - Suzic-Lazić, Jelena

AU - Zivanovic, Vladimir

AU - Jozika, Ljilja

AU - Celic, Vera

PY - 2015/12/12

Y1 - 2015/12/12

N2 - We sought to investigate the relationship between blood pressure (BP) variability and left atrial (LA) phasic function assessed by volumetric and speckle tracking method in normal-weight, overweight and obese hypertensive patients. This cross-sectional study included 164 untreated hypertensive subjects who underwent a 24-h ambulatory BP monitoring and complete two-dimensional echocardiographic examination (2DE). All the patients were separated into three groups according to their body mass index (BMI): normal-weight patients (BMI <25 kg/m2), overweight patients (25 ≤ BMI <30 kg/m2), and obese patients (BMI ≥ 30 kg/m2). Daytime, nighttime and 24 h BP variability indices were higher in obese hypertensive subjects than in lean patients. Maximum and minimum LA volumes and volume indexes gradually and significantly increased, whereas pre-A LAV decreased, from normal-weight to obese subjects. Total and passive LA emptying fractions, representing LA reservoir and conduit function, gradually reduced from lean to obese individuals. Active LA EF, the parameter of LA booster pump function, increased in the same direction. Similar results were obtained by 2DE strain analysis. BP variability parameters were associated with structural, functional and mechanical parameters of LA remodeling in the whole study population. The parameters of LA reservoir function were negatively related with BP variability indices, whereas the parameters of LA pump function were positively related with BP variability indices. Obesity significantly impacts BP variability and LA phasic function in untreated hypertensive subjects. BP variability is associated with LA remodeling independent of BP, left ventricular systolic and diastolic function.

AB - We sought to investigate the relationship between blood pressure (BP) variability and left atrial (LA) phasic function assessed by volumetric and speckle tracking method in normal-weight, overweight and obese hypertensive patients. This cross-sectional study included 164 untreated hypertensive subjects who underwent a 24-h ambulatory BP monitoring and complete two-dimensional echocardiographic examination (2DE). All the patients were separated into three groups according to their body mass index (BMI): normal-weight patients (BMI <25 kg/m2), overweight patients (25 ≤ BMI <30 kg/m2), and obese patients (BMI ≥ 30 kg/m2). Daytime, nighttime and 24 h BP variability indices were higher in obese hypertensive subjects than in lean patients. Maximum and minimum LA volumes and volume indexes gradually and significantly increased, whereas pre-A LAV decreased, from normal-weight to obese subjects. Total and passive LA emptying fractions, representing LA reservoir and conduit function, gradually reduced from lean to obese individuals. Active LA EF, the parameter of LA booster pump function, increased in the same direction. Similar results were obtained by 2DE strain analysis. BP variability parameters were associated with structural, functional and mechanical parameters of LA remodeling in the whole study population. The parameters of LA reservoir function were negatively related with BP variability indices, whereas the parameters of LA pump function were positively related with BP variability indices. Obesity significantly impacts BP variability and LA phasic function in untreated hypertensive subjects. BP variability is associated with LA remodeling independent of BP, left ventricular systolic and diastolic function.

KW - Hypertension

KW - Left atrium

KW - Obesity

KW - Overweight

KW - Two-dimensional strain

UR - http://www.scopus.com/inward/record.url?scp=84949683701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84949683701&partnerID=8YFLogxK

U2 - 10.1007/s10554-015-0822-8

DO - 10.1007/s10554-015-0822-8

M3 - Article

SP - 1

EP - 10

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

ER -