The relationship between carotid and coronary calcification in patients with coronary artery disease

Rafik Shenouda, Sergio Vancheri, Emilio Maria Bassi, Rachel Nicoll, Mohammed Sobhi, Eman El Sharkawy, Per Wester, Federico Vancheri, Michael Y. Henein

Research output: Contribution to journalArticlepeer-review


Background: Atherosclerosis is a multi-system pathology with heterogeneous involvement. We aimed to investigate the relationship between the presence and severity of carotid and coronary calcification in a group of patients with coronary artery disease. Methods: Sixty-three patients presenting with unstable angina or positive stress test for myocardial ischaemia were enrolled in this study. All patients underwent CT scanning of the carotid and coronary arteries using the conventional protocol and Agatston scoring system. Risk factors for atherosclerosis were also analyzed for correlation with the extent of arterial calcification. Results: Total coronary artery calcium score (CAC) was several times higher than total carotid calcium score (1274 (1018) vs 6 (124), p = 0·0001, respectively). The left carotid calcium score correlated strongly with the right carotid calcium score (rho = 0·69, p < 0·0001). The total CAC score correlated modestly with the total carotid calcium score (rho = 0·34, p = 0·007), in particular with left carotid score (rho = 0·38, p = 0·002), but not with the right carotid score. The left coronary calcium score correlated with the right coronary calcium score (rho = 0·35, p = 0·004), left carotid calcium score (rho = 0·33, p = 0·007) and left carotid calcium score at the bifurcation (rho = 0·34, p = 0·006). While hypertension correlated with carotid calcium score, diabetes and dyslipidaemia correlated with left CAC score. Conclusion: In patients with coronary disease, the carotid calcification pattern appeared to be similar between the right and left system in contrast to that of the coronary arteries. CAC correlated only modestly with the carotid score, despite being significantly higher. Hypertension was related to carotid calcium score while diabetes and dyslipidaemia correlated with coronary calcification.

Original languageEnglish
JournalClinical Physiology and Functional Imaging
Publication statusAccepted/In press - 2021


  • acute coronary syndrome
  • agatston score
  • carotid calcification
  • coronary calcification
  • CT scanning

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


Dive into the research topics of 'The relationship between carotid and coronary calcification in patients with coronary artery disease'. Together they form a unique fingerprint.

Cite this