The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study

Francesco Bolzetta, Nicola Veronese, Brendon Stubbs, Marianna Noale, Alberto Vaona, Jacopo Demurtas, Stefano Celotto, Chiara Cacco, Alberto Cester, Maria Gabriella Caruso, Rosa Reddavide, Maria Notarnicola, Stefania Maggi, Ai Koyanagi, Michele Fornaro, Joseph Firth, Lee Smith, Marco Solmi

Research output: Contribution to journalArticle

Abstract

Few studies assessed the associations between dietary vitamin K and depressive symptoms. We aimed to investigate the association between dietary vitamin K and depressive symptoms in a large cohort of North American People. In this cross-sectional analysis, 4,375 participants that were aged 45⁻79 years from the Osteoarthritis Initiative were included. Dietary vitamin K intake was collected through a semi-quantitative food frequency questionnaire and categorized in quartiles. Depressive symptoms were diagnosed using the 20-item Center for Epidemiologic Studies-Depression (CES-D) ≥ 16. To investigate the associations between vitamin K intake and depressive symptoms, logistic regression analysis were run, which adjusted for potential confounders. Overall, 437 (=10%) subjects had depressive symptoms. After adjusting for 11 confounders, people with the highest dietary vitamin K intake had lower odds of having depressive symptoms (OR = 0.58; 95%CI: 0.43⁻0.80). This effect was only present in people not taking vitamin D supplementation. In conclusion, higher dietary vitamin K intake was significantly associated with a lower presence of depressive symptoms, also after accounting for potential confounders. Future longitudinal research is required to explore the directionality of the association.

Original languageEnglish
Pages (from-to)787
JournalNutrients
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 5 2019

    Fingerprint

Cite this

Bolzetta, F., Veronese, N., Stubbs, B., Noale, M., Vaona, A., Demurtas, J., Celotto, S., Cacco, C., Cester, A., Caruso, M. G., Reddavide, R., Notarnicola, M., Maggi, S., Koyanagi, A., Fornaro, M., Firth, J., Smith, L., & Solmi, M. (2019). The Relationship between Dietary Vitamin K and Depressive Symptoms in Late Adulthood: A Cross-Sectional Analysis from a Large Cohort Study. Nutrients, 11(4), 787. https://doi.org/10.3390/nu11040787