The relationship between erectile dysfunction and open urethroplasty: A systematic review and meta-analysis

Chao Feng, Yue Min Xu, Guido Barbagli, Massimo Lazzeri, Chen Ye Tang, Qiang Fu, Ying Long Sa

Research output: Contribution to journalArticlepeer-review


Introduction: Various urethroplasty techniques have been used to treat urethral stricture. Whether the patient erectile function is affected by this open surgery is still controversial. Aim: The aim of this study is to determine the relationship between erectile function and open urethroplasty. Methods: A systematic review of the literature was performed using Medline, Embase, the Web of Science, and the Cochrane Library databases through October 2012 to identify articles published in any language that examined the effect of open urethroplasty on the risk of erectile dysfunction (ED). This meta-analysis was conducted according to the guidelines for the meta-analysis of observational studies in epidemiology. Main Outcome Measures: The incidence of ED after urethroplasty. Results: This meta-analysis consisted of 23 cohort studies, which included 1,729 cases. No significant difference was noticed in patients with anterior urethral stricture before or after intervention (odds ratio [OR]=0.86; 95% confidence interval [CI]: 0.52-1.40; P=0.53). While statistical difference in the incidence of ED was revealed in patients before and after intervention for a posterior urethral (OR=2.51; 95% CI: 1.82-3.45; P

Original languageEnglish
Pages (from-to)2060-2068
Number of pages9
JournalJournal of Sexual Medicine
Issue number8
Publication statusPublished - Aug 2013


  • Erectile Dysfunction
  • Meta-Analysis
  • Urethral Reconstructive Surgery
  • Urethroplasty

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Medicine(all)


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