The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity

Paolo Marzullo, Alessandro Minocci, Chiara Mele, Rezene Fessehatsion, Mariantonella Tagliaferri, Loredana Pagano, Massimo Scacchi, Gianluca Aimaretti, Alessandro Sartorio

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Abstract

Background Regulating thermogenesis is a major task of thyroid hormones (THs), and involves THresponsive energetic processes at the central and peripheral level. In severe obesity, little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss. Methods We enrolled 100 euthyroid subjects with severe obesity who were equally distributed between genders. Each was examined before and after completion of a 4-wk inpatient multidisciplinary dieting program and subjected to measurement of thyroid function, REE, fatfree mass (FFM, kg) and percent fat mass (FM). Results Baseline REE was lower than predicted in 70 obese patients, and overall associated with BMI, FFM and FM but not thyroid-related parameters. By the study end, both BMI and REE decreased (5.5% and 4.1%, p<0.001 vs. baseline) and their percent changes were significantly associated (p<0.05), while no association related percent changes of REE and FFM or FM. Individually, REE decreased in 66 and increased in 34 patients irrespective of gender, BMI and body composition. Weight loss significantly impacted TSH (-6.3%), FT3 (-3.3%) and FT4 levels (3.9%; p<0.001 for all). By the study end, a significant correlation became evident between REE and FT4 (r = 0.42, p<0.001) as well as FT3 (r = 0.24, p<0.05). In stepwise multivariable regression analysis, however, neither THs nor body composition entered the regression equation for REE response to weight loss. Conclusions In severe obesity, short-term weight loss discloses a positive relationship between REE and THs.

Original languageEnglish
Article numbere0205293
JournalPLoS One
Volume13
Issue number10
DOIs
Publication statusPublished - Oct 1 2018

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resting energy expenditure
Morbid Obesity
thyroid hormones
Thyroid Hormones
Energy Metabolism
Weight Loss
obesity
weight loss
Fats
Body Composition
body composition
Thyroid Gland
lipids
thyroid function
dieting
Thermogenesis
gender
heat production
Chemical analysis
Regression analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity. / Marzullo, Paolo; Minocci, Alessandro; Mele, Chiara; Fessehatsion, Rezene; Tagliaferri, Mariantonella; Pagano, Loredana; Scacchi, Massimo; Aimaretti, Gianluca; Sartorio, Alessandro.

In: PLoS One, Vol. 13, No. 10, e0205293, 01.10.2018.

Research output: Contribution to journalArticle

Marzullo, Paolo ; Minocci, Alessandro ; Mele, Chiara ; Fessehatsion, Rezene ; Tagliaferri, Mariantonella ; Pagano, Loredana ; Scacchi, Massimo ; Aimaretti, Gianluca ; Sartorio, Alessandro. / The relationship between resting energy expenditure and thyroid hormones in response to short-term weight loss in severe obesity. In: PLoS One. 2018 ; Vol. 13, No. 10.
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N2 - Background Regulating thermogenesis is a major task of thyroid hormones (THs), and involves THresponsive energetic processes at the central and peripheral level. In severe obesity, little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss. Methods We enrolled 100 euthyroid subjects with severe obesity who were equally distributed between genders. Each was examined before and after completion of a 4-wk inpatient multidisciplinary dieting program and subjected to measurement of thyroid function, REE, fatfree mass (FFM, kg) and percent fat mass (FM). Results Baseline REE was lower than predicted in 70 obese patients, and overall associated with BMI, FFM and FM but not thyroid-related parameters. By the study end, both BMI and REE decreased (5.5% and 4.1%, p<0.001 vs. baseline) and their percent changes were significantly associated (p<0.05), while no association related percent changes of REE and FFM or FM. Individually, REE decreased in 66 and increased in 34 patients irrespective of gender, BMI and body composition. Weight loss significantly impacted TSH (-6.3%), FT3 (-3.3%) and FT4 levels (3.9%; p<0.001 for all). By the study end, a significant correlation became evident between REE and FT4 (r = 0.42, p<0.001) as well as FT3 (r = 0.24, p<0.05). In stepwise multivariable regression analysis, however, neither THs nor body composition entered the regression equation for REE response to weight loss. Conclusions In severe obesity, short-term weight loss discloses a positive relationship between REE and THs.

AB - Background Regulating thermogenesis is a major task of thyroid hormones (THs), and involves THresponsive energetic processes at the central and peripheral level. In severe obesity, little is known on the relationship between THs and resting energy expenditure (REE) before and after weight loss. Methods We enrolled 100 euthyroid subjects with severe obesity who were equally distributed between genders. Each was examined before and after completion of a 4-wk inpatient multidisciplinary dieting program and subjected to measurement of thyroid function, REE, fatfree mass (FFM, kg) and percent fat mass (FM). Results Baseline REE was lower than predicted in 70 obese patients, and overall associated with BMI, FFM and FM but not thyroid-related parameters. By the study end, both BMI and REE decreased (5.5% and 4.1%, p<0.001 vs. baseline) and their percent changes were significantly associated (p<0.05), while no association related percent changes of REE and FFM or FM. Individually, REE decreased in 66 and increased in 34 patients irrespective of gender, BMI and body composition. Weight loss significantly impacted TSH (-6.3%), FT3 (-3.3%) and FT4 levels (3.9%; p<0.001 for all). By the study end, a significant correlation became evident between REE and FT4 (r = 0.42, p<0.001) as well as FT3 (r = 0.24, p<0.05). In stepwise multivariable regression analysis, however, neither THs nor body composition entered the regression equation for REE response to weight loss. Conclusions In severe obesity, short-term weight loss discloses a positive relationship between REE and THs.

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