The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis: data from the Osteoarthritis Initiative

Nicola Veronese, Nitin Shivappa, Brendon Stubbs, Toby Smith, James R. Hébert, Cyrus Cooper, Giuseppe Guglielmi, Jean Yves Reginster, Renè Rizzoli, Stefania Maggi

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate whether higher dietary inflammatory index (DII®) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database. Methods: A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII®) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Participants with a higher DII® score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII® score (quartile 4: 35.4% vs. quartile 1: 24.0%; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII® score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII® score (quartile 1). Conclusions: Higher DII® values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalEuropean Journal of Nutrition
DOIs
Publication statusAccepted/In press - Dec 5 2017

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Knee Osteoarthritis
Osteoarthritis
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Independent Living
Knee
Databases
Diet
Food

Keywords

  • Dietary inflammatory index
  • Inflammation
  • Knee osteoarthritis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis : data from the Osteoarthritis Initiative. / Veronese, Nicola; Shivappa, Nitin; Stubbs, Brendon; Smith, Toby; Hébert, James R.; Cooper, Cyrus; Guglielmi, Giuseppe; Reginster, Jean Yves; Rizzoli, Renè; Maggi, Stefania.

In: European Journal of Nutrition, 05.12.2017, p. 1-8.

Research output: Contribution to journalArticle

Veronese, Nicola ; Shivappa, Nitin ; Stubbs, Brendon ; Smith, Toby ; Hébert, James R. ; Cooper, Cyrus ; Guglielmi, Giuseppe ; Reginster, Jean Yves ; Rizzoli, Renè ; Maggi, Stefania. / The relationship between the dietary inflammatory index and prevalence of radiographic symptomatic osteoarthritis : data from the Osteoarthritis Initiative. In: European Journal of Nutrition. 2017 ; pp. 1-8.
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abstract = "Purpose: To investigate whether higher dietary inflammatory index (DII{\circledR}) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database. Methods: A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII{\circledR} scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII{\circledR}) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95{\%} confidence intervals (CIs). Results: Participants with a higher DII{\circledR} score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII{\circledR} score (quartile 4: 35.4{\%} vs. quartile 1: 24.0{\%}; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII{\circledR} score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95{\%} CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII{\circledR} score (quartile 1). Conclusions: Higher DII{\circledR} values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.",
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AU - Veronese, Nicola

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AU - Stubbs, Brendon

AU - Smith, Toby

AU - Hébert, James R.

AU - Cooper, Cyrus

AU - Guglielmi, Giuseppe

AU - Reginster, Jean Yves

AU - Rizzoli, Renè

AU - Maggi, Stefania

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N2 - Purpose: To investigate whether higher dietary inflammatory index (DII®) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database. Methods: A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII®) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Participants with a higher DII® score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII® score (quartile 4: 35.4% vs. quartile 1: 24.0%; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII® score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII® score (quartile 1). Conclusions: Higher DII® values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.

AB - Purpose: To investigate whether higher dietary inflammatory index (DII®) scores were associated with higher prevalence of radiographic symptomatic knee osteoarthritis in a large cohort of North American people from the Osteoarthritis Initiative database. Methods: A total of 4358 community-dwelling participants (2527 females; mean age 61.2 years) from the Osteoarthritis Initiative were identified. DII® scores were calculated using the validated Block Brief 2000 Food-Frequency Questionnaire and scores were categorized into quartiles. Knee radiographic symptomatic osteoarthritis was diagnosed clinically and radiologically. The strength of association between divided into quartiles (DII®) and knee osteoarthritis was investigated through a logistic regression analysis, which adjusted for potential confounders, and results were reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Participants with a higher DII® score, indicating a more pro-inflammatory diet, had a significantly higher prevalence of radiographic symptomatic knee osteoarthritis compared to those with lower DII® score (quartile 4: 35.4% vs. quartile 1: 24.0%; p < 0.0001). Using a logistic regression analysis, adjusting for 11 potential confounders, participants with the highest DII® score (quartile 4) had a significantly higher probability of experiencing radiographic symptomatic knee osteoarthritis (OR 1.40; 95% CI 1.14–1.72; p = 0.002) compared to participants with the lowest DII® score (quartile 1). Conclusions: Higher DII® values are associated with higher prevalence of radiographic symptomatic knee osteoarthritis.

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