The relationship between the Spine Deformity Index, biochemical parameters of bone metabolism and vascular calcifications: Results from the Epidemiological VERtebral FRACtures iTalian Study (EVERFRACT) in dialysis patients

Maria Fusaro, Maurizio Gallieni, Marianna Noale, Giovanni Tripepi, Davide Miozzo, Mario Plebani, Martina Zaninotto, Giuseppe Guglielmi, Diego Miotto, Fabrizio Fabris, Antonio Piccoli, Maria Teresa Vilei, Stefania Sella, Paolo Morachiello, Fabrizio Stoppa, Maurizio Rossini, Sandro Giannini

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The Spine Deformity Index (SDI) is a measure of vertebral fractures (VFs), providing information on both their number and severity.

Methods: We evaluated the relationships between SDI and clinical, biochemical and arterial calcification parameters in 387 hemodialysis (HD) patients. VFs, assessed by quantitative vertebral morphometry, and vascular calcifications were identified in the same lateral spinal X-ray. To improve the detection of fracture severity, we created a corrected SDI (c-SDI), by dividing SDI for the number of VFs. We assessed routine biochemistry, bone-Gla-protein (BGP), undercaboxylated BGP (ucBGP), and matrix-Gla-protein (MGP).

Results: VFs prevalence was 55.3%. HD patients with a SDI >1 were more frequently males (p1 had higher LDL-cholesterol (p1 (p1 (p1. Age (OR 1.05, CI 1.03-1.07), LDL-cholesterol (OR 1.74, CI 1.04-2.92) and ucBGP (OR 0.35, CI 0.18-0.70) were associated with c-SDI >1.

Conclusions: We conclude that the severity of VFs was associated with age, atherogenic factors and bone metabolism markers.

Original languageEnglish
Pages (from-to)1595-1603
Number of pages9
JournalClinical Chemistry and Laboratory Medicine
Volume52
Issue number11
DOIs
Publication statusPublished - Nov 19 2014

Keywords

  • arterial calcifications
  • hemodialysis
  • vertebral fractures

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Medicine(all)

Fingerprint Dive into the research topics of 'The relationship between the Spine Deformity Index, biochemical parameters of bone metabolism and vascular calcifications: Results from the Epidemiological VERtebral FRACtures iTalian Study (EVERFRACT) in dialysis patients'. Together they form a unique fingerprint.

Cite this