Background: The Spine Deformity Index (SDI) is a measure of vertebral fractures (VFs), providing information on both their number and severity.
Methods: We evaluated the relationships between SDI and clinical, biochemical and arterial calcification parameters in 387 hemodialysis (HD) patients. VFs, assessed by quantitative vertebral morphometry, and vascular calcifications were identified in the same lateral spinal X-ray. To improve the detection of fracture severity, we created a corrected SDI (c-SDI), by dividing SDI for the number of VFs. We assessed routine biochemistry, bone-Gla-protein (BGP), undercaboxylated BGP (ucBGP), and matrix-Gla-protein (MGP).
Results: VFs prevalence was 55.3%. HD patients with a SDI >1 were more frequently males (p1 had higher LDL-cholesterol (p1 (p1 (p1. Age (OR 1.05, CI 1.03-1.07), LDL-cholesterol (OR 1.74, CI 1.04-2.92) and ucBGP (OR 0.35, CI 0.18-0.70) were associated with c-SDI >1.
Conclusions: We conclude that the severity of VFs was associated with age, atherogenic factors and bone metabolism markers.
- arterial calcifications
- vertebral fractures
ASJC Scopus subject areas
- Clinical Biochemistry
- Biochemistry, medical