TY - JOUR
T1 - The relationship between the Spine Deformity Index, biochemical parameters of bone metabolism and vascular calcifications
T2 - Results from the Epidemiological VERtebral FRACtures iTalian Study (EVERFRACT) in dialysis patients
AU - Fusaro, Maria
AU - Gallieni, Maurizio
AU - Noale, Marianna
AU - Tripepi, Giovanni
AU - Miozzo, Davide
AU - Plebani, Mario
AU - Zaninotto, Martina
AU - Guglielmi, Giuseppe
AU - Miotto, Diego
AU - Fabris, Fabrizio
AU - Piccoli, Antonio
AU - Vilei, Maria Teresa
AU - Sella, Stefania
AU - Morachiello, Paolo
AU - Stoppa, Fabrizio
AU - Rossini, Maurizio
AU - Giannini, Sandro
PY - 2014/11/19
Y1 - 2014/11/19
N2 - Background: The Spine Deformity Index (SDI) is a measure of vertebral fractures (VFs), providing information on both their number and severity.Methods: We evaluated the relationships between SDI and clinical, biochemical and arterial calcification parameters in 387 hemodialysis (HD) patients. VFs, assessed by quantitative vertebral morphometry, and vascular calcifications were identified in the same lateral spinal X-ray. To improve the detection of fracture severity, we created a corrected SDI (c-SDI), by dividing SDI for the number of VFs. We assessed routine biochemistry, bone-Gla-protein (BGP), undercaboxylated BGP (ucBGP), and matrix-Gla-protein (MGP).Results: VFs prevalence was 55.3%. HD patients with a SDI >1 were more frequently males (p1 had higher LDL-cholesterol (p1 (p1 (p1. Age (OR 1.05, CI 1.03-1.07), LDL-cholesterol (OR 1.74, CI 1.04-2.92) and ucBGP (OR 0.35, CI 0.18-0.70) were associated with c-SDI >1.Conclusions: We conclude that the severity of VFs was associated with age, atherogenic factors and bone metabolism markers.
AB - Background: The Spine Deformity Index (SDI) is a measure of vertebral fractures (VFs), providing information on both their number and severity.Methods: We evaluated the relationships between SDI and clinical, biochemical and arterial calcification parameters in 387 hemodialysis (HD) patients. VFs, assessed by quantitative vertebral morphometry, and vascular calcifications were identified in the same lateral spinal X-ray. To improve the detection of fracture severity, we created a corrected SDI (c-SDI), by dividing SDI for the number of VFs. We assessed routine biochemistry, bone-Gla-protein (BGP), undercaboxylated BGP (ucBGP), and matrix-Gla-protein (MGP).Results: VFs prevalence was 55.3%. HD patients with a SDI >1 were more frequently males (p1 had higher LDL-cholesterol (p1 (p1 (p1. Age (OR 1.05, CI 1.03-1.07), LDL-cholesterol (OR 1.74, CI 1.04-2.92) and ucBGP (OR 0.35, CI 0.18-0.70) were associated with c-SDI >1.Conclusions: We conclude that the severity of VFs was associated with age, atherogenic factors and bone metabolism markers.
KW - arterial calcifications
KW - hemodialysis
KW - vertebral fractures
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U2 - 10.1515/cclm-2014-0194
DO - 10.1515/cclm-2014-0194
M3 - Article
C2 - 24897402
AN - SCOPUS:84908087205
VL - 52
SP - 1595
EP - 1603
JO - Clinical Chemistry and Laboratory Medicine
JF - Clinical Chemistry and Laboratory Medicine
SN - 1434-6621
IS - 11
ER -