The relationship of insulin resistance with SNP 276G>T at adiponectin gene and plasma long-chain polyunsaturated fatty acids in obese children

Elvira Verduci, Silvia Scaglioni, Carlo Agostoni, Giovanni Radaelli, Marialuisa Biondi, Ana S. Manso, Enrica Riva, Marcello Giovannini

Research output: Contribution to journalArticle

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Abstract

This study examined the association of insulin resistance with single-nucleotide polymorphism (SNP) 276G>T at adiponectin gene and the plasma long-chain polyunsaturated fatty acids (LCPUFAs) profile in obese children. One hundred thirty-one normolipidaemic obese children aged 8-13 y (53 girls and 68 boys) entered the study. The prevalence of T allele carriers at SNP276 was 48.8%. Mean [SD] values of fasting insulin and homeostasis model assessment-insulin resistance (HOMA-IR) index in noncarriers versus carriers of T allele were 12.4 [6.4] versus 20.6 [6.3] μU/mL (p = 0.039) and 2.6 [1.4] versus 4.5 [1.7] (p = 0.032). Mean [SD] values of plasma C18:3n - 3, C20:5w - 3/C20:4n - 6, and n - 6/n - 3 LCPUFA in phospholipids in noncarriers versus carriers of T allele were 0.10 [0.04] versus 0.08 [0.03] % (p = 0.013), 0.04 [0.01] versus 0.03 [0.01] % (p = 0.045), and 4.4 [0.7] versus 4.9 [0.9] % (p = 0.005), respectively. Insulin resistance was independently associated with SNP 276G>T (p = 0.002) and n - 6/n - 3 LCPUFA (p = 0.042) in plasma phospholipids, and interaction was found between SNP 276G>T and n - 6/n - 3 LCPUFA (p = 0.046). These findings suggest that obese children carriers of the SNP 276G>T may be at increased risk of metabolic complications compared with noncarriers, possibly due in part to a different plasma phospholipids profile.

Original languageEnglish
Pages (from-to)346-349
Number of pages4
JournalPediatric Research
Volume66
Issue number3
DOIs
Publication statusPublished - Sep 2009

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Adiponectin
Unsaturated Fatty Acids
Single Nucleotide Polymorphism
Insulin Resistance
Phospholipids
Alleles
Genes
Fasting
Homeostasis
Insulin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

The relationship of insulin resistance with SNP 276G>T at adiponectin gene and plasma long-chain polyunsaturated fatty acids in obese children. / Verduci, Elvira; Scaglioni, Silvia; Agostoni, Carlo; Radaelli, Giovanni; Biondi, Marialuisa; Manso, Ana S.; Riva, Enrica; Giovannini, Marcello.

In: Pediatric Research, Vol. 66, No. 3, 09.2009, p. 346-349.

Research output: Contribution to journalArticle

Verduci, Elvira ; Scaglioni, Silvia ; Agostoni, Carlo ; Radaelli, Giovanni ; Biondi, Marialuisa ; Manso, Ana S. ; Riva, Enrica ; Giovannini, Marcello. / The relationship of insulin resistance with SNP 276G>T at adiponectin gene and plasma long-chain polyunsaturated fatty acids in obese children. In: Pediatric Research. 2009 ; Vol. 66, No. 3. pp. 346-349.
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