Abstract
It has been reported that the incidence of thrombotic events can display a gender disparity. In particular, a lower thrombotic risk has been described in female gender. The mechanisms underlying this disparity are still poorly understood. Of great interest is the hypothesis that hormones, estrogen in particular, could play a key role. In fact, the possibility that some hormonal factors could protect women from thrombotic events appears well documented in literature. For instance, several studies aimed at the analysis of the impact of estrogen and estrogen receptors in thrombogenesis claim for the implication of these hormones either in megakaryocyte differentiation or, more intriguingly, directly affecting platelet integrity and function. In consideration of the absence of the nucleus, platelet susceptibility appears quite striking and probably due to the non-nuclear estrogen receptor function. In this review we briefly summarize our knowledge as concerns the role of estrogen and estrogen receptors in determining megakaryocyte/platelet functions and thrombogenicity.
| Original language | English |
|---|---|
| Pages (from-to) | 291-298 |
| Number of pages | 8 |
| Journal | International Journal of Cardiology |
| Volume | 187 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - May 6 2015 |
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Keywords
- Estrogen
- Estrogen receptors
- Megakaryocytes
- Platelets
- Thrombogenesis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Medicine(all)
Cite this
The relevance of estrogen/estrogen receptor system on the gender difference in cardiovascular risk. / Del Principe, Domenico; Ruggieri, Anna; Pietraforte, Donatella; Villani, Alberto; Vitale, Cristiana; Straface, Elisabetta; Malorni, Walter.
In: International Journal of Cardiology, Vol. 187, No. 1, 06.05.2015, p. 291-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The relevance of estrogen/estrogen receptor system on the gender difference in cardiovascular risk
AU - Del Principe, Domenico
AU - Ruggieri, Anna
AU - Pietraforte, Donatella
AU - Villani, Alberto
AU - Vitale, Cristiana
AU - Straface, Elisabetta
AU - Malorni, Walter
PY - 2015/5/6
Y1 - 2015/5/6
N2 - It has been reported that the incidence of thrombotic events can display a gender disparity. In particular, a lower thrombotic risk has been described in female gender. The mechanisms underlying this disparity are still poorly understood. Of great interest is the hypothesis that hormones, estrogen in particular, could play a key role. In fact, the possibility that some hormonal factors could protect women from thrombotic events appears well documented in literature. For instance, several studies aimed at the analysis of the impact of estrogen and estrogen receptors in thrombogenesis claim for the implication of these hormones either in megakaryocyte differentiation or, more intriguingly, directly affecting platelet integrity and function. In consideration of the absence of the nucleus, platelet susceptibility appears quite striking and probably due to the non-nuclear estrogen receptor function. In this review we briefly summarize our knowledge as concerns the role of estrogen and estrogen receptors in determining megakaryocyte/platelet functions and thrombogenicity.
AB - It has been reported that the incidence of thrombotic events can display a gender disparity. In particular, a lower thrombotic risk has been described in female gender. The mechanisms underlying this disparity are still poorly understood. Of great interest is the hypothesis that hormones, estrogen in particular, could play a key role. In fact, the possibility that some hormonal factors could protect women from thrombotic events appears well documented in literature. For instance, several studies aimed at the analysis of the impact of estrogen and estrogen receptors in thrombogenesis claim for the implication of these hormones either in megakaryocyte differentiation or, more intriguingly, directly affecting platelet integrity and function. In consideration of the absence of the nucleus, platelet susceptibility appears quite striking and probably due to the non-nuclear estrogen receptor function. In this review we briefly summarize our knowledge as concerns the role of estrogen and estrogen receptors in determining megakaryocyte/platelet functions and thrombogenicity.
KW - Estrogen
KW - Estrogen receptors
KW - Megakaryocytes
KW - Platelets
KW - Thrombogenesis
UR - http://www.scopus.com/inward/record.url?scp=84929167242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929167242&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2015.03.145
DO - 10.1016/j.ijcard.2015.03.145
M3 - Article
C2 - 25839625
AN - SCOPUS:84929167242
VL - 187
SP - 291
EP - 298
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 1
ER -