The relevance of immune reactions in acute favism

G. Fiorelli, M. Podda, A. Corrias, S. Fargion

Research output: Contribution to journalArticle

Abstract

In fava bean extracts the proteins were separated and characterized by gel filtration on Sephadex G-25 columns, cellogel electrophoresis and analytical ultracentrifugation. The dried extract and its chromatographic fractions were used to detect serum antibodies to fava beans by passive haemagglutination tests. 75 patients affected by acute favism were studied by this method. Haemagglutination tests were positive in 5 patients (6.6%) at the onset of the haemolytic crisis but a rapid fall of the titres was observed in the subsequent days. β1C1A and immunoglobulin levels showed no significant changes. Our results do not support the view that hypersensitivity to fava bean may be involved in the haemolysis of acute favism.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalActa Haematologica
Volume51
Issue number4
DOIs
Publication statusPublished - 1974

Keywords

  • Antibodies in favism
  • Fava bean extract
  • Favism
  • Gel filtration

ASJC Scopus subject areas

  • Hematology

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