BACKGROUND: Severe asthma in adolescents is a demanding challenge that deserves adequate management, including thorough work-up and rigorous follow-up. METHODS: We evaluated a group of adolescents with severe asthma to investigate the change over time of clinical, functional, and biological parameters. RESULTS: Most of adolescents treated with standard therapy improved, but some did not achieve an optimal asthma control and FeNO values increased. CONCLUSIONS: Despite guidelines-based therapy and clinical-functional improvement, type 2 inflammation could be not completely controlled. Biologics option could be considered if biomarkers suggest potential asthma relapse.
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