The RELN locus in Alzheimer's disease

Davide Seripa, Maria Giovanna Matera, Marilisa Franceschi, Antonio Daniele, Alessandra Bizzarro, Monica Rinaldi, Francesco Panza, Vito Michele Fazio, Carolina Gravina, Grazia D'Onofrio, Vincenzo Solfrizzi, Carlo Masullo, Alberto Pilotto

Research output: Contribution to journalArticle

Abstract

Reelin, a serine protease encoded by the RELN gene, is part of the apolipoprotein E (apoE) biochemical pathway that is involved in the pathogenesis of Alzheimer's disease (AD). Sex-related differences in the epidemiology, pathology and clinical characteristics of AD have been reported. To explore the potential contribution of RELN gene variants in the pathogenesis of AD, we investigated three polymorphisms spanning the RELN locus, i.e., a triplet tandem repeat in the 5'UTR and two single-nucleotide polymorphisms (SNPs) rs607755 and rs2229874, located in the splice-junction of exon 6 and in the coding region of exon 50. The analysis was made in 223 sporadic AD patients and 181 age-matched controls of Caucasian ethnicity. Significant differences between AD patients and controls were found in distribution of 5'UTR and rs607755 genotypes, whereas no differences were found in the distribution of rs2229874 genotypes. When patients and controls were divided according to sex, significant differences in genotype distribution were found in females and not in males, also after adjustment for APOE genotypes. These findings suggest that RELN gene variants may play a role in the pathogenesis of AD, particularly in females.

Original languageEnglish
Pages (from-to)335-344
Number of pages10
JournalJournal of Alzheimer's Disease
Volume14
Issue number3
Publication statusPublished - 2008

Keywords

  • Alzheimer's disease
  • Apolipoprotein E
  • Case-control studies
  • Gene polymorphism
  • Reelin
  • RELN
  • Risk factors
  • Single-nucleotide polymorphism

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology

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  • Cite this

    Seripa, D., Matera, M. G., Franceschi, M., Daniele, A., Bizzarro, A., Rinaldi, M., Panza, F., Fazio, V. M., Gravina, C., D'Onofrio, G., Solfrizzi, V., Masullo, C., & Pilotto, A. (2008). The RELN locus in Alzheimer's disease. Journal of Alzheimer's Disease, 14(3), 335-344.