The renin–angiotensin–aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19

Cássia L. Braga, Rodrigo P. Silva-Aguiar, Denise Battaglini, Diogo B. Peruchetti, Chiara Robba, Paolo Pelosi, Patricia R.M. Rocco, Celso Caruso-Neves, Pedro L. Silva

Research output: Contribution to journalReview articlepeer-review

Abstract

Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS-CoV-2 and SARS-CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID-19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID-19 and potential therapeutic targets, focusing on the role of the renin–angiotensin–aldosterone system.

Original languageEnglish
Article numbere00623
JournalPharmacology Research and Perspectives
Volume8
Issue number4
DOIs
Publication statusPublished - Aug 1 2020

Keywords

  • angiotensin-converting enzyme
  • COVID-19
  • inflammation
  • SARS-CoV-2
  • therapy

ASJC Scopus subject areas

  • Neurology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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