The RESTORE study: Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema

Paul Mitchell, Francesco Bandello, Ursula Schmidt-Erfurth, Gabriele E. Lang, Pascale Massin, Reinier O. Schlingemann, Florian Sutter, Christian Simader, Gabriela Burian, Ortrud Gerstner, Andreas Weichselberger

Research output: Contribution to journalArticle

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Abstract

Objective: To demonstrate superiority of ranibizumab 0.5 mg monotherapy or combined with laser over laser alone based on mean average change in best-corrected visual acuity (BCVA) over 12 months in diabetic macular edema (DME). Design: A 12-month, randomized, double-masked, multicenter, laser-controlled phase III study. Participants: We included 345 patients aged 73 (20/40 Snellen equivalent) with ranibizumab (22.6% and 53%, respectively) and ranibizumab + laser (22.9% and 44.9%) versus laser (8.2% and 23.6%). The mean central retinal thickness was significantly reduced from baseline with ranibizumab (-118.7 μm) and ranibizumab + laser (-128.3 μm) versus laser (-61.3 μm; both P

Original languageEnglish
Pages (from-to)615-625
Number of pages11
JournalOphthalmology
Volume118
Issue number4
DOIs
Publication statusPublished - Apr 2011

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Macular Edema
Lasers
compound A 12
Ranibizumab
Visual Acuity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Mitchell, P., Bandello, F., Schmidt-Erfurth, U., Lang, G. E., Massin, P., Schlingemann, R. O., ... Weichselberger, A. (2011). The RESTORE study: Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology, 118(4), 615-625. https://doi.org/10.1016/j.ophtha.2011.01.031

The RESTORE study : Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. / Mitchell, Paul; Bandello, Francesco; Schmidt-Erfurth, Ursula; Lang, Gabriele E.; Massin, Pascale; Schlingemann, Reinier O.; Sutter, Florian; Simader, Christian; Burian, Gabriela; Gerstner, Ortrud; Weichselberger, Andreas.

In: Ophthalmology, Vol. 118, No. 4, 04.2011, p. 615-625.

Research output: Contribution to journalArticle

Mitchell, P, Bandello, F, Schmidt-Erfurth, U, Lang, GE, Massin, P, Schlingemann, RO, Sutter, F, Simader, C, Burian, G, Gerstner, O & Weichselberger, A 2011, 'The RESTORE study: Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema', Ophthalmology, vol. 118, no. 4, pp. 615-625. https://doi.org/10.1016/j.ophtha.2011.01.031
Mitchell, Paul ; Bandello, Francesco ; Schmidt-Erfurth, Ursula ; Lang, Gabriele E. ; Massin, Pascale ; Schlingemann, Reinier O. ; Sutter, Florian ; Simader, Christian ; Burian, Gabriela ; Gerstner, Ortrud ; Weichselberger, Andreas. / The RESTORE study : Ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. In: Ophthalmology. 2011 ; Vol. 118, No. 4. pp. 615-625.
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