The RET proto-oncogene is expressed in predominantly epithelial human thymomas

N. Fabien, C. Paulin, M. Santoro, G. Chiappetta, G. Botti, M. Grieco, P. M. Dubois, A. Fusco

Research output: Contribution to journalArticle

Abstract

Thymomas are thymic tumors composed of epithelial cells with various number of lymphocytes. On the basis of lymphocytes number, they can be histologically classified into predominantly lymphocytic, predominantly epithelial and mixed lympho-epithelial. These tumors are rare and their prognosis is not well known yet. In this study we demonstrate by in situ hybridization the presence of RET transcripts in the medullary part of normal murine thymus and in epithelial thymomas. Conversely RET expression was not detected in the cortical part of the thymus and in thymomas with the predominance of the lymphocytic component, suggesting that its expression could be a specific marker of the predominantly epithelial histotype.

Original languageEnglish
Pages (from-to)489-493
Number of pages5
JournalInternational Journal of Oncology
Volume5
Issue number3
Publication statusPublished - 1994

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Thymoma
Proto-Oncogenes
Lymphocyte Count
Thymus Gland
Thymus Neoplasms
In Situ Hybridization
Epithelial Cells
Neoplasms

Keywords

  • In situ hybridization
  • RET proto-oncogene
  • Thymoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fabien, N., Paulin, C., Santoro, M., Chiappetta, G., Botti, G., Grieco, M., ... Fusco, A. (1994). The RET proto-oncogene is expressed in predominantly epithelial human thymomas. International Journal of Oncology, 5(3), 489-493.

The RET proto-oncogene is expressed in predominantly epithelial human thymomas. / Fabien, N.; Paulin, C.; Santoro, M.; Chiappetta, G.; Botti, G.; Grieco, M.; Dubois, P. M.; Fusco, A.

In: International Journal of Oncology, Vol. 5, No. 3, 1994, p. 489-493.

Research output: Contribution to journalArticle

Fabien, N, Paulin, C, Santoro, M, Chiappetta, G, Botti, G, Grieco, M, Dubois, PM & Fusco, A 1994, 'The RET proto-oncogene is expressed in predominantly epithelial human thymomas', International Journal of Oncology, vol. 5, no. 3, pp. 489-493.
Fabien N, Paulin C, Santoro M, Chiappetta G, Botti G, Grieco M et al. The RET proto-oncogene is expressed in predominantly epithelial human thymomas. International Journal of Oncology. 1994;5(3):489-493.
Fabien, N. ; Paulin, C. ; Santoro, M. ; Chiappetta, G. ; Botti, G. ; Grieco, M. ; Dubois, P. M. ; Fusco, A. / The RET proto-oncogene is expressed in predominantly epithelial human thymomas. In: International Journal of Oncology. 1994 ; Vol. 5, No. 3. pp. 489-493.
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