The retinoblastoma gene product in acute myeloid leukemia

A possible involvement in promyelocytic leukemia

M. G. Paggi, P. De Fabritiis, F. Bonetto, L. Amadio, G. Santarelli, A. Spadea, F. P. Gentile, A. Floridi, A. Felsani

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The retinoblastoma susceptibility gene in leukemia and lymphoma has been investigated using different approaches involving either gene or protein analysis. In this study, a novel method, which evaluates the functional status of the retinoblastoma gene product by a binding assay to an in vitro- translated viral oncoprotein, has been applied to leukemic cells from acute myeloid leukemia patients. One hundred twenty-two cases were considered, and 42 of them were also analyzed by Western blot. Results obtained with the two methods were comparable, with the exception of few cases, where the retinoblastoma protein appeared detectable but unable to bind to the vital oncoprotein. The retinoblastoma protein has been found defective mostly in the M3 promyelocytic subtype.

Original languageEnglish
Pages (from-to)4552-4556
Number of pages5
JournalCancer Research
Volume55
Issue number20
Publication statusPublished - 1995

Fingerprint

Retinoblastoma Genes
Retinoblastoma Protein
Oncogene Proteins
Acute Myeloid Leukemia
Leukemia
Lymphoma
Western Blotting
Proteins
In Vitro Techniques

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Paggi, M. G., De Fabritiis, P., Bonetto, F., Amadio, L., Santarelli, G., Spadea, A., ... Felsani, A. (1995). The retinoblastoma gene product in acute myeloid leukemia: A possible involvement in promyelocytic leukemia. Cancer Research, 55(20), 4552-4556.

The retinoblastoma gene product in acute myeloid leukemia : A possible involvement in promyelocytic leukemia. / Paggi, M. G.; De Fabritiis, P.; Bonetto, F.; Amadio, L.; Santarelli, G.; Spadea, A.; Gentile, F. P.; Floridi, A.; Felsani, A.

In: Cancer Research, Vol. 55, No. 20, 1995, p. 4552-4556.

Research output: Contribution to journalArticle

Paggi, MG, De Fabritiis, P, Bonetto, F, Amadio, L, Santarelli, G, Spadea, A, Gentile, FP, Floridi, A & Felsani, A 1995, 'The retinoblastoma gene product in acute myeloid leukemia: A possible involvement in promyelocytic leukemia', Cancer Research, vol. 55, no. 20, pp. 4552-4556.
Paggi, M. G. ; De Fabritiis, P. ; Bonetto, F. ; Amadio, L. ; Santarelli, G. ; Spadea, A. ; Gentile, F. P. ; Floridi, A. ; Felsani, A. / The retinoblastoma gene product in acute myeloid leukemia : A possible involvement in promyelocytic leukemia. In: Cancer Research. 1995 ; Vol. 55, No. 20. pp. 4552-4556.
@article{21238aa278074e1499d9e89dadffb30f,
title = "The retinoblastoma gene product in acute myeloid leukemia: A possible involvement in promyelocytic leukemia",
abstract = "The retinoblastoma susceptibility gene in leukemia and lymphoma has been investigated using different approaches involving either gene or protein analysis. In this study, a novel method, which evaluates the functional status of the retinoblastoma gene product by a binding assay to an in vitro- translated viral oncoprotein, has been applied to leukemic cells from acute myeloid leukemia patients. One hundred twenty-two cases were considered, and 42 of them were also analyzed by Western blot. Results obtained with the two methods were comparable, with the exception of few cases, where the retinoblastoma protein appeared detectable but unable to bind to the vital oncoprotein. The retinoblastoma protein has been found defective mostly in the M3 promyelocytic subtype.",
author = "Paggi, {M. G.} and {De Fabritiis}, P. and F. Bonetto and L. Amadio and G. Santarelli and A. Spadea and Gentile, {F. P.} and A. Floridi and A. Felsani",
year = "1995",
language = "English",
volume = "55",
pages = "4552--4556",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research Inc.",
number = "20",

}

TY - JOUR

T1 - The retinoblastoma gene product in acute myeloid leukemia

T2 - A possible involvement in promyelocytic leukemia

AU - Paggi, M. G.

AU - De Fabritiis, P.

AU - Bonetto, F.

AU - Amadio, L.

AU - Santarelli, G.

AU - Spadea, A.

AU - Gentile, F. P.

AU - Floridi, A.

AU - Felsani, A.

PY - 1995

Y1 - 1995

N2 - The retinoblastoma susceptibility gene in leukemia and lymphoma has been investigated using different approaches involving either gene or protein analysis. In this study, a novel method, which evaluates the functional status of the retinoblastoma gene product by a binding assay to an in vitro- translated viral oncoprotein, has been applied to leukemic cells from acute myeloid leukemia patients. One hundred twenty-two cases were considered, and 42 of them were also analyzed by Western blot. Results obtained with the two methods were comparable, with the exception of few cases, where the retinoblastoma protein appeared detectable but unable to bind to the vital oncoprotein. The retinoblastoma protein has been found defective mostly in the M3 promyelocytic subtype.

AB - The retinoblastoma susceptibility gene in leukemia and lymphoma has been investigated using different approaches involving either gene or protein analysis. In this study, a novel method, which evaluates the functional status of the retinoblastoma gene product by a binding assay to an in vitro- translated viral oncoprotein, has been applied to leukemic cells from acute myeloid leukemia patients. One hundred twenty-two cases were considered, and 42 of them were also analyzed by Western blot. Results obtained with the two methods were comparable, with the exception of few cases, where the retinoblastoma protein appeared detectable but unable to bind to the vital oncoprotein. The retinoblastoma protein has been found defective mostly in the M3 promyelocytic subtype.

UR - http://www.scopus.com/inward/record.url?scp=0028884207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028884207&partnerID=8YFLogxK

M3 - Article

VL - 55

SP - 4552

EP - 4556

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 20

ER -