Abstract
The retinoblastoma susceptibility gene in leukemia and lymphoma has been investigated using different approaches involving either gene or protein analysis. In this study, a novel method, which evaluates the functional status of the retinoblastoma gene product by a binding assay to an in vitro- translated viral oncoprotein, has been applied to leukemic cells from acute myeloid leukemia patients. One hundred twenty-two cases were considered, and 42 of them were also analyzed by Western blot. Results obtained with the two methods were comparable, with the exception of few cases, where the retinoblastoma protein appeared detectable but unable to bind to the vital oncoprotein. The retinoblastoma protein has been found defective mostly in the M3 promyelocytic subtype.
| Original language | English |
|---|---|
| Pages (from-to) | 4552-4556 |
| Number of pages | 5 |
| Journal | Cancer Research |
| Volume | 55 |
| Issue number | 20 |
| Publication status | Published - 1995 |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
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The retinoblastoma gene product in acute myeloid leukemia : A possible involvement in promyelocytic leukemia. / Paggi, M. G.; De Fabritiis, P.; Bonetto, F.; Amadio, L.; Santarelli, G.; Spadea, A.; Gentile, F. P.; Floridi, A.; Felsani, A.
In: Cancer Research, Vol. 55, No. 20, 1995, p. 4552-4556.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The retinoblastoma gene product in acute myeloid leukemia
T2 - A possible involvement in promyelocytic leukemia
AU - Paggi, M. G.
AU - De Fabritiis, P.
AU - Bonetto, F.
AU - Amadio, L.
AU - Santarelli, G.
AU - Spadea, A.
AU - Gentile, F. P.
AU - Floridi, A.
AU - Felsani, A.
PY - 1995
Y1 - 1995
N2 - The retinoblastoma susceptibility gene in leukemia and lymphoma has been investigated using different approaches involving either gene or protein analysis. In this study, a novel method, which evaluates the functional status of the retinoblastoma gene product by a binding assay to an in vitro- translated viral oncoprotein, has been applied to leukemic cells from acute myeloid leukemia patients. One hundred twenty-two cases were considered, and 42 of them were also analyzed by Western blot. Results obtained with the two methods were comparable, with the exception of few cases, where the retinoblastoma protein appeared detectable but unable to bind to the vital oncoprotein. The retinoblastoma protein has been found defective mostly in the M3 promyelocytic subtype.
AB - The retinoblastoma susceptibility gene in leukemia and lymphoma has been investigated using different approaches involving either gene or protein analysis. In this study, a novel method, which evaluates the functional status of the retinoblastoma gene product by a binding assay to an in vitro- translated viral oncoprotein, has been applied to leukemic cells from acute myeloid leukemia patients. One hundred twenty-two cases were considered, and 42 of them were also analyzed by Western blot. Results obtained with the two methods were comparable, with the exception of few cases, where the retinoblastoma protein appeared detectable but unable to bind to the vital oncoprotein. The retinoblastoma protein has been found defective mostly in the M3 promyelocytic subtype.
UR - http://www.scopus.com/inward/record.url?scp=0028884207&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028884207&partnerID=8YFLogxK
M3 - Article
VL - 55
SP - 4552
EP - 4556
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0008-5472
IS - 20
ER -