The ret/ptc1 oncogene is activated in familial adenomatous polyposis- associated thyroid papillary carcinomas

Francesco Cetta, Gennaro Chiappetta, Rosa Marina Melillo, Margherita Petracci, Giulia Montalto, Massimo Santoro, Alfredo Fusco

Research output: Contribution to journalArticle

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Abstract

Familial adenomatous polyposis (FAP) is caused by germ-line mutations of the apc gene, and it is associated with an increased risk of developing papillary thyroid carcinomas. We have previously reported that a significant fraction of sporadic human papillary thyroid carcinomas is characterized by gene rearrangements affecting the ret protooncogene. These rearrangements generate chimeric transforming oncogenes designated ret/ptc. By a combined immunohistochemical and RT-PCR approach, we analyzed, for ret/ptc encogene activation, papillary thyroid carcinomas occurred in two FAP kindreds, both showing typical apc gene mutations. Kindred 1 had seven members affected by FAP, and among these, three patients showed papillary thyroid carcinomas. Kindred 2 had two patients, mother and daughter, affected by colonic polyposis; the 20-yr-old daughter showed also a papillary carcinoma. Here we report that ret/ptc1 oncogene was activated in two of the three papillary carcinomas of FAP kindred 1 and in the papillary carcinoma of FAP kindred 2. These findings document that loss of function of apc coexists with gain of function of ret in some papillary thyroid carcinomas, suggesting that ret/ptc1 oncogene activation could be a progression step in the development of FAP-associated thyroid tumors.

Original languageEnglish
Pages (from-to)1003-1006
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume83
Issue number3
DOIs
Publication statusPublished - 1998

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Adenomatous Polyposis Coli
Oncogenes
Genes
Papillary Carcinoma
Chemical activation
Nuclear Family
Tumors
Germ-Line Mutation
Gene Rearrangement
Papillary Thyroid cancer
Thyroid Gland
Mothers
Polymerase Chain Reaction
Mutation
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

The ret/ptc1 oncogene is activated in familial adenomatous polyposis- associated thyroid papillary carcinomas. / Cetta, Francesco; Chiappetta, Gennaro; Melillo, Rosa Marina; Petracci, Margherita; Montalto, Giulia; Santoro, Massimo; Fusco, Alfredo.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 83, No. 3, 1998, p. 1003-1006.

Research output: Contribution to journalArticle

Cetta, F, Chiappetta, G, Melillo, RM, Petracci, M, Montalto, G, Santoro, M & Fusco, A 1998, 'The ret/ptc1 oncogene is activated in familial adenomatous polyposis- associated thyroid papillary carcinomas', Journal of Clinical Endocrinology and Metabolism, vol. 83, no. 3, pp. 1003-1006. https://doi.org/10.1210/jc.83.3.1003
Cetta, Francesco ; Chiappetta, Gennaro ; Melillo, Rosa Marina ; Petracci, Margherita ; Montalto, Giulia ; Santoro, Massimo ; Fusco, Alfredo. / The ret/ptc1 oncogene is activated in familial adenomatous polyposis- associated thyroid papillary carcinomas. In: Journal of Clinical Endocrinology and Metabolism. 1998 ; Vol. 83, No. 3. pp. 1003-1006.
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