The revolution in migraine genetics: From aching channels disorders to a next-generation medicine

Simona Pellacani, Federico Sicca, Cherubino Di Lorenzo, Gaetano S. Grieco, Giulia Valvo, Cristina Cereda, Anna Rubegni, Filippo M. Santorelli

Research output: Contribution to journalReview article

Abstract

Channelopathies are a heterogeneous group of neurological disorders resulting from dysfunction of ion channels located in cell membranes and organelles. The clinical scenario is broad and symptoms such as generalized epilepsy (with or without fever), migraine (with or without aura), episodic ataxia and periodic muscle paralysis are some of the best known consequences of gain- or loss-of-function mutations in ion channels. We review the main clinical effects of ion channel mutations associated with a significant impact on migraine headache. Given the increasing and evolving use of genetic analysis in migraine research—greater emphasis is now placed on genetic markers of dysfunctional biological systems—we also show how novel information in rare monogenic forms of migraine might help to clarify the disease mechanisms in the general population of migraineurs. Next-generation sequencing (NGS) and more accurate and precise phenotyping strategies are expected to further increase understanding of migraine pathophysiology and genetics.

Original languageEnglish
Article number156
JournalFrontiers in Cellular Neuroscience
Volume10
Issue numberJUN
DOIs
Publication statusPublished - Jun 13 2016

Fingerprint

Migraine Disorders
Ion Channels
Medicine
Channelopathies
Migraine without Aura
Migraine with Aura
Generalized Epilepsy
Mutation
Nervous System Diseases
Genetic Markers
Paralysis
Organelles
Fever
Cell Membrane
Muscles
Population

Keywords

  • Astrocyte
  • Calcium channel
  • Glutamate
  • Migraine
  • Sodium channel
  • Tripartite synapse

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

The revolution in migraine genetics : From aching channels disorders to a next-generation medicine. / Pellacani, Simona; Sicca, Federico; Lorenzo, Cherubino Di; Grieco, Gaetano S.; Valvo, Giulia; Cereda, Cristina; Rubegni, Anna; Santorelli, Filippo M.

In: Frontiers in Cellular Neuroscience, Vol. 10, No. JUN, 156, 13.06.2016.

Research output: Contribution to journalReview article

Pellacani, S, Sicca, F, Lorenzo, CD, Grieco, GS, Valvo, G, Cereda, C, Rubegni, A & Santorelli, FM 2016, 'The revolution in migraine genetics: From aching channels disorders to a next-generation medicine', Frontiers in Cellular Neuroscience, vol. 10, no. JUN, 156. https://doi.org/10.3389/fncel.2016.00156
Pellacani, Simona ; Sicca, Federico ; Lorenzo, Cherubino Di ; Grieco, Gaetano S. ; Valvo, Giulia ; Cereda, Cristina ; Rubegni, Anna ; Santorelli, Filippo M. / The revolution in migraine genetics : From aching channels disorders to a next-generation medicine. In: Frontiers in Cellular Neuroscience. 2016 ; Vol. 10, No. JUN.
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