The RIFLE criteria and mortality in acute kidney injury: A systematic review

Z. Ricci, D. Cruz, C. Ronco

Research output: Contribution to journalArticle

Abstract

In 2004, the Acute Dialysis Quality Initiative workgroup proposed a multilevel classification system for acute kidney injury (AKI) identified by the acronym RIFLE (Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease). Several studies have been published aiming to validate and apply it in clinical practice, verifying whether outcome progressively worsened with the severity of AKI. A literature search from August 2004 to June 2007 was conducted: 24 studies in which the RIFLE classification was used to define AKI were identified. In 13 studies, patient-level data on mortality were available for Risk, Injury, and Failure patients, as well as those without AKI (non-AKI). Death was reported at ICU discharge, hospital discharge, 28, 30, 60, and 90 days. The pooled estimate of relative risk (RR) for mortality for patients with R, I, or F levels compared with non-AKI patients were analyzed. Over 71 000 patients were included in the analysis of published reports. With respect to non-AKI, there appeared to be a stepwise increase in RR for death going from Risk (RR=2.40) to Injury (RR=4.15) to Failure (6.37, P

Original languageEnglish
Pages (from-to)538-546
Number of pages9
JournalKidney International
Volume73
Issue number5
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Acute renal failure definition
  • Epidemiology
  • Outcome
  • RIFLE criteria

ASJC Scopus subject areas

  • Nephrology

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