Rischio di iperomocisteinemia in pazienti con epilessia, portatori del diplotipo C677T/A1298C della MTHFR

G. Gorgone; D. Caccamo; S. Condello; V. Belcastro; D. Italiano; L. R. Pisani; G. Badolato; P. Striano; G. Oteri; R. Ientile; F. Pisani

Rischio di iperomocisteinemia in pazienti con epilessia, portatori del diplotipo C677T/A1298C della MTHFR

Translated title of the contribution: The risk of hyperhomocysteinemia in patients with epilepsy exhibiting the diplotype C677T/A1298C of MTHFR

G. Gorgone, D. Caccamo, S. Condello, V. Belcastro, D. Italiano, L. R. Pisani, G. Badolato, P. Striano, G. Oteri, R. Ientile, F. Pisani

Research output: Contribution to journal › Article › peer-review

Abstract

This study was aimed at investigating the impact of antiepileptic drugs (AEDs) on hyperhomocysteinemia (hyper-Hcy) in 71 epileptic patients (pts) (40 M, 31 F; 19-41 aa) exhibiting the CT677/AC1298 diplotype of MTHFR gene. 26 pt (36.6%) showed hyper-Hcy (> 13 μmol/); of them, 20 were treated with enzyme-inducing AEDs and 6 with enzyme-inducing AEDs added on to non enzyme inducing drugs. Pts exclusively treated with enzyme-inducing AEDs exhibited lower serum folate concentrations (3.28 ± 1.82 nmol/L p <0.01) and higher plasma Hey levels (18.32 ± 5.52 μmol/L p <0.001) as compared to other groups. These pts showed a positive risk association for hyper-Hcy (OR = 3.8, CI = 1.04-14.4). Folate supplementation (5 mg/day) restored both Hcy and folate levels within the normal ranges.

Translated title of the contribution	The risk of hyperhomocysteinemia in patients with epilepsy exhibiting the diplotype C677T/A1298C of MTHFR
Original language	Italian
Pages (from-to)	21-23
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	129-130
Publication status	Published - 2005

ASJC Scopus subject areas

Clinical Neurology

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title = "Rischio di iperomocisteinemia in pazienti con epilessia, portatori del diplotipo C677T/A1298C della MTHFR",

abstract = "This study was aimed at investigating the impact of antiepileptic drugs (AEDs) on hyperhomocysteinemia (hyper-Hcy) in 71 epileptic patients (pts) (40 M, 31 F; 19-41 aa) exhibiting the CT677/AC1298 diplotype of MTHFR gene. 26 pt (36.6%) showed hyper-Hcy (> 13 μmol/); of them, 20 were treated with enzyme-inducing AEDs and 6 with enzyme-inducing AEDs added on to non enzyme inducing drugs. Pts exclusively treated with enzyme-inducing AEDs exhibited lower serum folate concentrations (3.28 ± 1.82 nmol/L p <0.01) and higher plasma Hey levels (18.32 ± 5.52 μmol/L p <0.001) as compared to other groups. These pts showed a positive risk association for hyper-Hcy (OR = 3.8, CI = 1.04-14.4). Folate supplementation (5 mg/day) restored both Hcy and folate levels within the normal ranges.",

keywords = "Antiepileptic drugs, Epilepsy, Folate, Hyperhomocysteinemia, MTHFR",

author = "G. Gorgone and D. Caccamo and S. Condello and V. Belcastro and D. Italiano and Pisani, {L. R.} and G. Badolato and P. Striano and G. Oteri and R. Ientile and F. Pisani",

year = "2005",

language = "Italian",

pages = "21--23",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

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publisher = "Lega Italiana contro l'Epilessia",

number = "129-130",

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T1 - Rischio di iperomocisteinemia in pazienti con epilessia, portatori del diplotipo C677T/A1298C della MTHFR

AU - Gorgone, G.

AU - Caccamo, D.

AU - Condello, S.

AU - Belcastro, V.

AU - Italiano, D.

AU - Pisani, L. R.

AU - Badolato, G.

AU - Striano, P.

AU - Oteri, G.

AU - Ientile, R.

AU - Pisani, F.

PY - 2005

Y1 - 2005

N2 - This study was aimed at investigating the impact of antiepileptic drugs (AEDs) on hyperhomocysteinemia (hyper-Hcy) in 71 epileptic patients (pts) (40 M, 31 F; 19-41 aa) exhibiting the CT677/AC1298 diplotype of MTHFR gene. 26 pt (36.6%) showed hyper-Hcy (> 13 μmol/); of them, 20 were treated with enzyme-inducing AEDs and 6 with enzyme-inducing AEDs added on to non enzyme inducing drugs. Pts exclusively treated with enzyme-inducing AEDs exhibited lower serum folate concentrations (3.28 ± 1.82 nmol/L p <0.01) and higher plasma Hey levels (18.32 ± 5.52 μmol/L p <0.001) as compared to other groups. These pts showed a positive risk association for hyper-Hcy (OR = 3.8, CI = 1.04-14.4). Folate supplementation (5 mg/day) restored both Hcy and folate levels within the normal ranges.

AB - This study was aimed at investigating the impact of antiepileptic drugs (AEDs) on hyperhomocysteinemia (hyper-Hcy) in 71 epileptic patients (pts) (40 M, 31 F; 19-41 aa) exhibiting the CT677/AC1298 diplotype of MTHFR gene. 26 pt (36.6%) showed hyper-Hcy (> 13 μmol/); of them, 20 were treated with enzyme-inducing AEDs and 6 with enzyme-inducing AEDs added on to non enzyme inducing drugs. Pts exclusively treated with enzyme-inducing AEDs exhibited lower serum folate concentrations (3.28 ± 1.82 nmol/L p <0.01) and higher plasma Hey levels (18.32 ± 5.52 μmol/L p <0.001) as compared to other groups. These pts showed a positive risk association for hyper-Hcy (OR = 3.8, CI = 1.04-14.4). Folate supplementation (5 mg/day) restored both Hcy and folate levels within the normal ranges.

KW - Antiepileptic drugs

KW - Epilepsy

KW - Folate

KW - Hyperhomocysteinemia

KW - MTHFR

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JO - Bollettino - Lega Italiana contro l'Epilessia

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Rischio di iperomocisteinemia in pazienti con epilessia, portatori del diplotipo C677T/A1298C della MTHFR

Abstract

ASJC Scopus subject areas

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