Abstract
This study was aimed at investigating the impact of antiepileptic drugs (AEDs) on hyperhomocysteinemia (hyper-Hcy) in 71 epileptic patients (pts) (40 M, 31 F; 19-41 aa) exhibiting the CT677/AC1298 diplotype of MTHFR gene. 26 pt (36.6%) showed hyper-Hcy (> 13 μmol/); of them, 20 were treated with enzyme-inducing AEDs and 6 with enzyme-inducing AEDs added on to non enzyme inducing drugs. Pts exclusively treated with enzyme-inducing AEDs exhibited lower serum folate concentrations (3.28 ± 1.82 nmol/L p <0.01) and higher plasma Hey levels (18.32 ± 5.52 μmol/L p <0.001) as compared to other groups. These pts showed a positive risk association for hyper-Hcy (OR = 3.8, CI = 1.04-14.4). Folate supplementation (5 mg/day) restored both Hcy and folate levels within the normal ranges.
Translated title of the contribution | The risk of hyperhomocysteinemia in patients with epilepsy exhibiting the diplotype C677T/A1298C of MTHFR |
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Original language | Italian |
Pages (from-to) | 21-23 |
Number of pages | 3 |
Journal | Bollettino - Lega Italiana contro l'Epilessia |
Issue number | 129-130 |
Publication status | Published - 2005 |
ASJC Scopus subject areas
- Clinical Neurology