The risk of preeclampsia beyond the first pregnancy among women with type 1 diabetes parity and preeclampsia in type 1 diabetes

M. T. Castiglioni, L. Valsecchi, P. Cavoretto, S. Pirola, L. Di Piazza, L. Maggio, A. Caretto, T. S. Garito, S. Rosa, M. Scavini

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Aim To estimate the incidence of preeclampsia (PE) among nulliparous and multiparous patients with type 1 diabetes and to study predictors of PE. Methods We prospectively collected data on all pregnancies of patients with pregestational type 1 diabetes, followed at our Prenatal Medicine Unit between 1993 and 2008. Medical records were prospectively reviewed by two obstetricians for maternal demographics, pregnancy data, maternal and fetal outcomes. Data were analyzed according to the development of PE and parity. Results We identified and collected data on 291 eligible pregnancies (195 among nulliparae and 96 among multiparae). The incidence of PE was 9.2% (95% CI: 5.6-14.2) among nulliparae and 9.4% (95% CI: 4.4-17.0) among multiparae. Patients who developed PE had higher HbA1c during pregnancy compared to patients who did not (p = 0.026 among nulliparae and p = 0.032 among multiparae). Chronic hypertension [OR 17.12 (3.22, 91.00)], microalbuminuria at the beginning of the pregnancy [OR 3.77 (1.22, 11.61)], weight gain during pregnancy [OR 1.13 (1.04, 1.23)] and HbA1c in the first trimester [2.81 (1.12, 7.05)], but not parity, were significant predictors of PE. Conclusions Among patients with type 1 diabetes the incidence of PE was similar among nulliparae and multiparae, unlikely in the general population where PE is a disease of the first pregnancy. An increased risk of PE should be assumed for both nulliparous and multiparous women with pregestational diabetes .

Original languageEnglish
Pages (from-to)34-40
Number of pages7
JournalPregnancy Hypertension
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2014

Fingerprint

Pre-Eclampsia
Parity
Type 1 Diabetes Mellitus
Pregnancy
Incidence
Mothers
First Pregnancy Trimester
Weight Gain
Medical Records
Medicine
Demography
Hypertension
Population

Keywords

  • Diabetes mellitus type 1
  • Preeclampsia
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Internal Medicine

Cite this

The risk of preeclampsia beyond the first pregnancy among women with type 1 diabetes parity and preeclampsia in type 1 diabetes. / Castiglioni, M. T.; Valsecchi, L.; Cavoretto, P.; Pirola, S.; Di Piazza, L.; Maggio, L.; Caretto, A.; Garito, T. S.; Rosa, S.; Scavini, M.

In: Pregnancy Hypertension, Vol. 4, No. 1, 01.2014, p. 34-40.

Research output: Contribution to journalArticle

Castiglioni, M. T. ; Valsecchi, L. ; Cavoretto, P. ; Pirola, S. ; Di Piazza, L. ; Maggio, L. ; Caretto, A. ; Garito, T. S. ; Rosa, S. ; Scavini, M. / The risk of preeclampsia beyond the first pregnancy among women with type 1 diabetes parity and preeclampsia in type 1 diabetes. In: Pregnancy Hypertension. 2014 ; Vol. 4, No. 1. pp. 34-40.
@article{7560de11aa9046dc8887ba22556d0f28,
title = "The risk of preeclampsia beyond the first pregnancy among women with type 1 diabetes parity and preeclampsia in type 1 diabetes",
abstract = "Aim To estimate the incidence of preeclampsia (PE) among nulliparous and multiparous patients with type 1 diabetes and to study predictors of PE. Methods We prospectively collected data on all pregnancies of patients with pregestational type 1 diabetes, followed at our Prenatal Medicine Unit between 1993 and 2008. Medical records were prospectively reviewed by two obstetricians for maternal demographics, pregnancy data, maternal and fetal outcomes. Data were analyzed according to the development of PE and parity. Results We identified and collected data on 291 eligible pregnancies (195 among nulliparae and 96 among multiparae). The incidence of PE was 9.2{\%} (95{\%} CI: 5.6-14.2) among nulliparae and 9.4{\%} (95{\%} CI: 4.4-17.0) among multiparae. Patients who developed PE had higher HbA1c during pregnancy compared to patients who did not (p = 0.026 among nulliparae and p = 0.032 among multiparae). Chronic hypertension [OR 17.12 (3.22, 91.00)], microalbuminuria at the beginning of the pregnancy [OR 3.77 (1.22, 11.61)], weight gain during pregnancy [OR 1.13 (1.04, 1.23)] and HbA1c in the first trimester [2.81 (1.12, 7.05)], but not parity, were significant predictors of PE. Conclusions Among patients with type 1 diabetes the incidence of PE was similar among nulliparae and multiparae, unlikely in the general population where PE is a disease of the first pregnancy. An increased risk of PE should be assumed for both nulliparous and multiparous women with pregestational diabetes .",
keywords = "Diabetes mellitus type 1, Preeclampsia, Pregnancy",
author = "Castiglioni, {M. T.} and L. Valsecchi and P. Cavoretto and S. Pirola and {Di Piazza}, L. and L. Maggio and A. Caretto and Garito, {T. S.} and S. Rosa and M. Scavini",
year = "2014",
month = "1",
doi = "10.1016/j.preghy.2013.09.001",
language = "English",
volume = "4",
pages = "34--40",
journal = "Pregnancy Hypertension",
issn = "2210-7789",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - The risk of preeclampsia beyond the first pregnancy among women with type 1 diabetes parity and preeclampsia in type 1 diabetes

AU - Castiglioni, M. T.

AU - Valsecchi, L.

AU - Cavoretto, P.

AU - Pirola, S.

AU - Di Piazza, L.

AU - Maggio, L.

AU - Caretto, A.

AU - Garito, T. S.

AU - Rosa, S.

AU - Scavini, M.

PY - 2014/1

Y1 - 2014/1

N2 - Aim To estimate the incidence of preeclampsia (PE) among nulliparous and multiparous patients with type 1 diabetes and to study predictors of PE. Methods We prospectively collected data on all pregnancies of patients with pregestational type 1 diabetes, followed at our Prenatal Medicine Unit between 1993 and 2008. Medical records were prospectively reviewed by two obstetricians for maternal demographics, pregnancy data, maternal and fetal outcomes. Data were analyzed according to the development of PE and parity. Results We identified and collected data on 291 eligible pregnancies (195 among nulliparae and 96 among multiparae). The incidence of PE was 9.2% (95% CI: 5.6-14.2) among nulliparae and 9.4% (95% CI: 4.4-17.0) among multiparae. Patients who developed PE had higher HbA1c during pregnancy compared to patients who did not (p = 0.026 among nulliparae and p = 0.032 among multiparae). Chronic hypertension [OR 17.12 (3.22, 91.00)], microalbuminuria at the beginning of the pregnancy [OR 3.77 (1.22, 11.61)], weight gain during pregnancy [OR 1.13 (1.04, 1.23)] and HbA1c in the first trimester [2.81 (1.12, 7.05)], but not parity, were significant predictors of PE. Conclusions Among patients with type 1 diabetes the incidence of PE was similar among nulliparae and multiparae, unlikely in the general population where PE is a disease of the first pregnancy. An increased risk of PE should be assumed for both nulliparous and multiparous women with pregestational diabetes .

AB - Aim To estimate the incidence of preeclampsia (PE) among nulliparous and multiparous patients with type 1 diabetes and to study predictors of PE. Methods We prospectively collected data on all pregnancies of patients with pregestational type 1 diabetes, followed at our Prenatal Medicine Unit between 1993 and 2008. Medical records were prospectively reviewed by two obstetricians for maternal demographics, pregnancy data, maternal and fetal outcomes. Data were analyzed according to the development of PE and parity. Results We identified and collected data on 291 eligible pregnancies (195 among nulliparae and 96 among multiparae). The incidence of PE was 9.2% (95% CI: 5.6-14.2) among nulliparae and 9.4% (95% CI: 4.4-17.0) among multiparae. Patients who developed PE had higher HbA1c during pregnancy compared to patients who did not (p = 0.026 among nulliparae and p = 0.032 among multiparae). Chronic hypertension [OR 17.12 (3.22, 91.00)], microalbuminuria at the beginning of the pregnancy [OR 3.77 (1.22, 11.61)], weight gain during pregnancy [OR 1.13 (1.04, 1.23)] and HbA1c in the first trimester [2.81 (1.12, 7.05)], but not parity, were significant predictors of PE. Conclusions Among patients with type 1 diabetes the incidence of PE was similar among nulliparae and multiparae, unlikely in the general population where PE is a disease of the first pregnancy. An increased risk of PE should be assumed for both nulliparous and multiparous women with pregestational diabetes .

KW - Diabetes mellitus type 1

KW - Preeclampsia

KW - Pregnancy

UR - http://www.scopus.com/inward/record.url?scp=84894302353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894302353&partnerID=8YFLogxK

U2 - 10.1016/j.preghy.2013.09.001

DO - 10.1016/j.preghy.2013.09.001

M3 - Article

VL - 4

SP - 34

EP - 40

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

SN - 2210-7789

IS - 1

ER -