The RNA editing enzymes ADARs: Mechanism of action and human disease

Sara Tomaselli, Franco Locatelli, Angela Gallo

Research output: Contribution to journalArticlepeer-review

Abstract

A-to-I RNA editing is a ubiquitous and crucial molecular mechanism able to convert adenosines into inosines (then read as guanosines by several intracellular proteins/enzymes) within RNA molecules, changing the genomic information. The A-to-I deaminase enzymes (ADARs), which modify the adenosine, can alter the splicing and translation machineries, the double-stranded RNA structures and the binding affinity between RNA and RNA-binding proteins. ADAR activity is an essential mechanism in mammals and altered editing has been associated with several human diseases. Many efforts are now being concentrated on modifying ADAR activity in vivo in an attempt to correct RNA editing dysfunction. Concomitantly, ongoing studies aim to show the way that the ADAR deaminase domain can be used as a possible new tool, an intracellular Trojan horse, for the correction of heritage diseases not related to RNA editing events.

Original languageEnglish
Pages (from-to)527-532
Number of pages6
JournalCell & Tissue Research
Volume356
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • ADARs
  • Heterochromatin
  • Human diseases
  • Inosine
  • RNA editing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Cell Biology
  • Histology
  • Medicine(all)

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