The role of α-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study

Nicola Glorioso, Paolo Manunta, Fabiana Filigheddu, Chiara Troffa, Paola Stella, Cristina Barlassina, Cinzia Lombardi, Aldo Soro, Francesco Dettori, Paolo Pinna Parpaglia, Maria Teresa Sciarrone Alibrandi, Daniele Cusi, Giuseppe Bianchi

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

The basic requirement for declaring an association study positive is that the 'hypertension-favoring' allele is more frequent in hypertensive cases than in normotensive controls. However, both positive and negative associations with hypertension have been found for the same polymorphism when studied in different populations. In the present study, we addressed the question of the possible cause(s) of this discrepancy among populations by using the α-adducin polymorphism as a paradigm. Four hundred ninety hypertensives and 176 normotensives enrolled in Sassari, Italy, and 468 hypertensives and 181 normotensives enrolled in Milano, Italy, were genotyped for the α-adducin Gly460Trp polymorphism. The blood pressure response to 2 months of hydrochlorothiazide therapy could be evaluated in 143 (85 in Sassari and 58 in Milano) hypertensives with and without the 460Trp α- adducin allele. The α-adducin 460Trp allele was not significantly more frequent in hypertensives in the Sassari population but was more frequent in hypertensives than in normotensives in Milano (P=0.019). Basal plasma renin activity was lower and blood pressure fall after diuretic therapy more pronounced (P

Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalHypertension
Volume34
Issue number4 I
Publication statusPublished - Oct 1999

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Sodium
Blood Pressure
Alleles
Italy
Population
Hypertension
Hydrochlorothiazide
Diuretics
Renin
adducin
Therapeutics

Keywords

  • Adducin
  • Genes
  • Hypertension, genetic
  • Renin
  • Sodium

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Glorioso, N., Manunta, P., Filigheddu, F., Troffa, C., Stella, P., Barlassina, C., ... Bianchi, G. (1999). The role of α-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study. Hypertension, 34(4 I), 649-654.

The role of α-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study. / Glorioso, Nicola; Manunta, Paolo; Filigheddu, Fabiana; Troffa, Chiara; Stella, Paola; Barlassina, Cristina; Lombardi, Cinzia; Soro, Aldo; Dettori, Francesco; Parpaglia, Paolo Pinna; Alibrandi, Maria Teresa Sciarrone; Cusi, Daniele; Bianchi, Giuseppe.

In: Hypertension, Vol. 34, No. 4 I, 10.1999, p. 649-654.

Research output: Contribution to journalArticle

Glorioso, N, Manunta, P, Filigheddu, F, Troffa, C, Stella, P, Barlassina, C, Lombardi, C, Soro, A, Dettori, F, Parpaglia, PP, Alibrandi, MTS, Cusi, D & Bianchi, G 1999, 'The role of α-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study', Hypertension, vol. 34, no. 4 I, pp. 649-654.
Glorioso, Nicola ; Manunta, Paolo ; Filigheddu, Fabiana ; Troffa, Chiara ; Stella, Paola ; Barlassina, Cristina ; Lombardi, Cinzia ; Soro, Aldo ; Dettori, Francesco ; Parpaglia, Paolo Pinna ; Alibrandi, Maria Teresa Sciarrone ; Cusi, Daniele ; Bianchi, Giuseppe. / The role of α-adducin polymorphism in blood pressure and sodium handling regulation may not be excluded by a negative association study. In: Hypertension. 1999 ; Vol. 34, No. 4 I. pp. 649-654.
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