The role of 18F-FDG PET/CT in soft tissue sarcoma

Andrea Sambri; Giuseppe Bianchi; Alessandra Longhi; Alberto Righi; Davide Maria Donati; Cristina Nanni; Stefano Fanti; Costantino Errani

doi:10.1097/MNM.0000000000001002

The role of 18F-FDG PET/CT in soft tissue sarcoma

Andrea Sambri, Giuseppe Bianchi, Alessandra Longhi, Alberto Righi, Davide Maria Donati, Cristina Nanni, Stefano Fanti, Costantino Errani

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Our aim was to evaluate F-FDG uptake in different STS types and to assess the prognostic value of the maximum standardized uptake value (SUVmax).

PATIENTS AND METHODS: We reviewed 50 adult patients with primary high-grade STS of the extremities with a preoperative PET. Overall survival and local recurrence were analysed.

RESULTS: The mean SUVmax was 12.9 (range: 2.2-33.4). All cases of myxoid liposarcoma and all cases of synovial sarcoma had SUVmax of less than 10.3. A better overall survival and local recurrence were observed in patients with SUVmax of less than 10.3 (P=0.005 and 0.046, respectively).

CONCLUSION: SUVmax seems to be specific among different STS histotypes. PET does not seem to be useful in myxoid liposarcoma as well as synovial sarcoma as these tumours seem to have a low uptake of glucose. SUVmax might also be included as a prognostic factor.

Original language	English
Pages (from-to)	626-631
Number of pages	6
Journal	Nuclear Medicine Communications
Volume	40
Issue number	6
Early online date	Mar 22 2019
DOIs	https://doi.org/10.1097/MNM.0000000000001002
Publication status	Published - Jun 2019

Keywords

liposarcoma
PET
prognosis
soft tissue sarcoma
synovial sarcoma

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@article{13a233738e1b4721b40a4f8215f7ead1,

title = "The role of 18F-FDG PET/CT in soft tissue sarcoma",

abstract = "INTRODUCTION: Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Our aim was to evaluate F-FDG uptake in different STS types and to assess the prognostic value of the maximum standardized uptake value (SUVmax).PATIENTS AND METHODS: We reviewed 50 adult patients with primary high-grade STS of the extremities with a preoperative PET. Overall survival and local recurrence were analysed.RESULTS: The mean SUVmax was 12.9 (range: 2.2-33.4). All cases of myxoid liposarcoma and all cases of synovial sarcoma had SUVmax of less than 10.3. A better overall survival and local recurrence were observed in patients with SUVmax of less than 10.3 (P=0.005 and 0.046, respectively).CONCLUSION: SUVmax seems to be specific among different STS histotypes. PET does not seem to be useful in myxoid liposarcoma as well as synovial sarcoma as these tumours seem to have a low uptake of glucose. SUVmax might also be included as a prognostic factor.",

keywords = "liposarcoma, PET, prognosis, soft tissue sarcoma, synovial sarcoma",

author = "Andrea Sambri and Giuseppe Bianchi and Alessandra Longhi and Alberto Righi and Donati, {Davide Maria} and Cristina Nanni and Stefano Fanti and Costantino Errani",

year = "2019",

month = jun,

doi = "10.1097/MNM.0000000000001002",

language = "English",

volume = "40",

pages = "626--631",

journal = "Nuclear Medicine Communications",

issn = "0143-3636",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - The role of 18F-FDG PET/CT in soft tissue sarcoma

AU - Sambri, Andrea

AU - Bianchi, Giuseppe

AU - Longhi, Alessandra

AU - Righi, Alberto

AU - Donati, Davide Maria

AU - Nanni, Cristina

AU - Fanti, Stefano

AU - Errani, Costantino

PY - 2019/6

Y1 - 2019/6

N2 - INTRODUCTION: Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Our aim was to evaluate F-FDG uptake in different STS types and to assess the prognostic value of the maximum standardized uptake value (SUVmax).PATIENTS AND METHODS: We reviewed 50 adult patients with primary high-grade STS of the extremities with a preoperative PET. Overall survival and local recurrence were analysed.RESULTS: The mean SUVmax was 12.9 (range: 2.2-33.4). All cases of myxoid liposarcoma and all cases of synovial sarcoma had SUVmax of less than 10.3. A better overall survival and local recurrence were observed in patients with SUVmax of less than 10.3 (P=0.005 and 0.046, respectively).CONCLUSION: SUVmax seems to be specific among different STS histotypes. PET does not seem to be useful in myxoid liposarcoma as well as synovial sarcoma as these tumours seem to have a low uptake of glucose. SUVmax might also be included as a prognostic factor.

AB - INTRODUCTION: Soft tissue sarcomas (STS) are highly fluorine-18-fluorodeoxyglucose (F-FDG)-avid tumours. PET seems to be effective for the assessment of the extent of disease. However, the use of PET to stratify STS into different risk histotypes still remains controversial. Our aim was to evaluate F-FDG uptake in different STS types and to assess the prognostic value of the maximum standardized uptake value (SUVmax).PATIENTS AND METHODS: We reviewed 50 adult patients with primary high-grade STS of the extremities with a preoperative PET. Overall survival and local recurrence were analysed.RESULTS: The mean SUVmax was 12.9 (range: 2.2-33.4). All cases of myxoid liposarcoma and all cases of synovial sarcoma had SUVmax of less than 10.3. A better overall survival and local recurrence were observed in patients with SUVmax of less than 10.3 (P=0.005 and 0.046, respectively).CONCLUSION: SUVmax seems to be specific among different STS histotypes. PET does not seem to be useful in myxoid liposarcoma as well as synovial sarcoma as these tumours seem to have a low uptake of glucose. SUVmax might also be included as a prognostic factor.

KW - liposarcoma

KW - PET

KW - prognosis

KW - soft tissue sarcoma

KW - synovial sarcoma

U2 - 10.1097/MNM.0000000000001002

DO - 10.1097/MNM.0000000000001002

M3 - Article

C2 - 30908341

VL - 40

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EP - 631

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 6

ER -