The Role of 18F-FDG PET/CT in Staging and Prognostication of Mantle Cell Lymphoma: An Italian Multicentric Study

Young Italian Association of Nuclear Medicine, Domenico Albano, Riccardo Laudicella, Paola Ferro, Michela Allocca, Elisabetta Abenavoli, Ambra Buschiazzo, Alessia Castellino, Agostino Chiaravalloti, Annarosa Cuccaro, Lea Cuppari, Rexhep Durmo, Laura Evangelista, Viviana Frantellizzi, Sofya Kovalchuk, Flavia Linguanti, Giulia Santo, Matteo Bauckneht, Salvatore Annunziata

Research output: Contribution to journalArticlepeer-review

Abstract

Mantle cell lymphoma (MCL) is an aggressive lymphoma subtype with poor prognosis in which 18F-FDG-PET/CT role in treatment response evaluation and prediction of outcome is still unclear. The aim of this multicentric study was to investigate the role of 18F-FDG-PET/CT in staging MCL and the prognostic role of Deauville criteria (DC) in terms of progression-free survival (PFS) and overall survival (OS). We retrospectively enrolled 229 patients who underwent baseline and end-of-treatment (eot) 18F-FDG-PET/CT after first-line therapy. EotPET/CT scans were visually interpreted according to DC. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of bone marrow (BM) were 27%, 100%, 100%, 48% and 57%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of PET/CT for evaluation of the gastrointestinal (GI) tract were 60%, 99%, 93%, 90% and 91%, respectively. At a median follow-up of 40 months, relapse occurred in 104 cases and death in 49. EotPET/CT results using DC significantly correlated with PFS, not with OS. Instead, considering OS, only MIPI score was significantly correlated. In conclusion, we demonstrated that MCL is an FDG-avid lymphoma and 18F-FDG-PET/CT is a useful tool for staging purpose, showing good specificity for BM and GI evaluation, but suboptimal sensitivity. EotPET/CT result was the only independent significant prognostic factor that correlated with PFS.
Original languageEnglish
Article number1831
Pages (from-to)1-12
Number of pages12
JournalCancers
Volume11
Issue number12
DOIs
Publication statusPublished - Nov 21 2019

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