The role of a fixed Berberis aristata/Silybum marianum combination in the treatment of type 1 diabetes mellitus

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Abstract

Aim: To evaluate if the addition of Berberis aristata/Silybum marianum (Berberol®) leads to a reduction of insulin dose and to an improvement of glycemic control in patients with type 1 diabetes mellitus. Material and methods: 85 type 1 diabetic patients were enrolled and randomized to take placebo or B. aristata/. S. marianum 588/105mg, 1 tablet at lunch and 1 tablet at dinner, for six months. We evaluated if there was a reduction of insulin dose necessary to reach an adequate glycemic control. We also evaluated at the study start, and after 6 months: body mass index (BMI), glycated hemoglobin, fasting plasma glucose (FPG), post-prandial glucose (PPG), lipid profile. Results: We observed a reduction of total insulin consumption in B. aristata/. S. marianum, both compared to baseline and to placebo. Regarding insulin administration at meals, we recorded that the group treated with B. aristata/. S. marianum used less insulin at meals, and at bedtime. Glycated hemoglobin decreased with B. aristata/. S. marianum compared to baseline, but not compared to placebo. There was a decrease of FPG, and PPG with B. aristata/. S. marianum both compared to baseline and to placebo. Regarding lipid profile, we recorded a decrease of total cholesterol, triglycerides, and LDL-cholesterol and an increase of HDL-cholesterol with B. aristata/. S. marianum, both compared to baseline and to placebo. Conclusions: The addition of B. aristata/. S. marianum to insulin therapy in patients with type 1 diabetes mellitus leads to a reduction of the insulin dose necessary to have an adequate glycemic control.

Original languageEnglish
JournalClinical Nutrition
DOIs
Publication statusAccepted/In press - Jan 4 2015

Keywords

  • Berberis aristata
  • Insulin consumption
  • Silybum marianum
  • Type 1 diabetes mellitus

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

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