The role of adducin in hypertension

Cristina Barlassina, Paolo Manunta, Giuseppe Bianchi

Research output: Contribution to journalArticle

Abstract

This article reviews recent information on the identification of adducin as a 'candidate' gene in the Milan hypertensive strain (MHS) of rats, a genetic model of essential hypertension, and in human essential hypertension. In MHS rats, the sequence of events beginning from renal function to cell membrane ion transport abnormalities and finally to the molecular defect has been established. The cytoskeletal protein adducin was identified as a candidate for the pathogenesis of hypertension in these rats, and polymorphisms in its gene that are involved in blood pressure regulation were identified. A polymorphism in the human α-adducin gene (Gly460Trp) is significantly associated with hypertension. Both in humans and in rats, adducin polymorphisms may affect blood pressure and kidney function by modulating the overall capacity of tubular epithelial cells to transport ions. In conclusion, adducin polymorphisms account for only a portion of hypertension both in humans and in rats. Therefore, additive or epistatic interactions with other genes involved in renal sodium handling need to be studied.

Original languageEnglish
Pages (from-to)229-233
Number of pages5
JournalCurrent Opinion in Endocrinology and Diabetes
Volume5
Issue number3
DOIs
Publication statusPublished - 1998

Fingerprint

Hypertension
Ion Transport
Kidney
Genes
Blood Pressure
Cytoskeletal Proteins
Genetic Models
Epithelial Cells
Sodium
Cell Membrane
adducin
Essential Hypertension

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

The role of adducin in hypertension. / Barlassina, Cristina; Manunta, Paolo; Bianchi, Giuseppe.

In: Current Opinion in Endocrinology and Diabetes, Vol. 5, No. 3, 1998, p. 229-233.

Research output: Contribution to journalArticle

Barlassina, Cristina ; Manunta, Paolo ; Bianchi, Giuseppe. / The role of adducin in hypertension. In: Current Opinion in Endocrinology and Diabetes. 1998 ; Vol. 5, No. 3. pp. 229-233.
@article{3b8e52b0b17d40d8995905bef8646b7b,
title = "The role of adducin in hypertension",
abstract = "This article reviews recent information on the identification of adducin as a 'candidate' gene in the Milan hypertensive strain (MHS) of rats, a genetic model of essential hypertension, and in human essential hypertension. In MHS rats, the sequence of events beginning from renal function to cell membrane ion transport abnormalities and finally to the molecular defect has been established. The cytoskeletal protein adducin was identified as a candidate for the pathogenesis of hypertension in these rats, and polymorphisms in its gene that are involved in blood pressure regulation were identified. A polymorphism in the human α-adducin gene (Gly460Trp) is significantly associated with hypertension. Both in humans and in rats, adducin polymorphisms may affect blood pressure and kidney function by modulating the overall capacity of tubular epithelial cells to transport ions. In conclusion, adducin polymorphisms account for only a portion of hypertension both in humans and in rats. Therefore, additive or epistatic interactions with other genes involved in renal sodium handling need to be studied.",
author = "Cristina Barlassina and Paolo Manunta and Giuseppe Bianchi",
year = "1998",
doi = "10.1097/00060793-199806000-00014",
language = "English",
volume = "5",
pages = "229--233",
journal = "Current Opinion in Endocrinology and Diabetes",
issn = "1068-3097",
publisher = "Rapid Science Publishers",
number = "3",

}

TY - JOUR

T1 - The role of adducin in hypertension

AU - Barlassina, Cristina

AU - Manunta, Paolo

AU - Bianchi, Giuseppe

PY - 1998

Y1 - 1998

N2 - This article reviews recent information on the identification of adducin as a 'candidate' gene in the Milan hypertensive strain (MHS) of rats, a genetic model of essential hypertension, and in human essential hypertension. In MHS rats, the sequence of events beginning from renal function to cell membrane ion transport abnormalities and finally to the molecular defect has been established. The cytoskeletal protein adducin was identified as a candidate for the pathogenesis of hypertension in these rats, and polymorphisms in its gene that are involved in blood pressure regulation were identified. A polymorphism in the human α-adducin gene (Gly460Trp) is significantly associated with hypertension. Both in humans and in rats, adducin polymorphisms may affect blood pressure and kidney function by modulating the overall capacity of tubular epithelial cells to transport ions. In conclusion, adducin polymorphisms account for only a portion of hypertension both in humans and in rats. Therefore, additive or epistatic interactions with other genes involved in renal sodium handling need to be studied.

AB - This article reviews recent information on the identification of adducin as a 'candidate' gene in the Milan hypertensive strain (MHS) of rats, a genetic model of essential hypertension, and in human essential hypertension. In MHS rats, the sequence of events beginning from renal function to cell membrane ion transport abnormalities and finally to the molecular defect has been established. The cytoskeletal protein adducin was identified as a candidate for the pathogenesis of hypertension in these rats, and polymorphisms in its gene that are involved in blood pressure regulation were identified. A polymorphism in the human α-adducin gene (Gly460Trp) is significantly associated with hypertension. Both in humans and in rats, adducin polymorphisms may affect blood pressure and kidney function by modulating the overall capacity of tubular epithelial cells to transport ions. In conclusion, adducin polymorphisms account for only a portion of hypertension both in humans and in rats. Therefore, additive or epistatic interactions with other genes involved in renal sodium handling need to be studied.

UR - http://www.scopus.com/inward/record.url?scp=0031807353&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031807353&partnerID=8YFLogxK

U2 - 10.1097/00060793-199806000-00014

DO - 10.1097/00060793-199806000-00014

M3 - Article

VL - 5

SP - 229

EP - 233

JO - Current Opinion in Endocrinology and Diabetes

JF - Current Opinion in Endocrinology and Diabetes

SN - 1068-3097

IS - 3

ER -