TY - JOUR
T1 - The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus
AU - Weisz, Filippo
AU - Piccinin, Sonia
AU - Mango, Dalila
AU - Ngomba, Richard Teke
AU - Mercuri, Nicola B.
AU - Nicoletti, Ferdinando
AU - Nisticò, Robert
PY - 2017/5/1
Y1 - 2017/5/1
N2 - In the last two decades adiponectin, member of the adipokines family, gained attention because of its unique antidiabetic effects. However, the presence in the brain of adiponectin receptors and adiponectin itself raised interest because of the possible association with neuropsychiatric diseases. Indeed, clinical studies found altered concentration of adiponectin both in plasma and cerebrospinal fluid in several pathologies including depression, multiple sclerosis, Alzheimer's disease and stroke. Moreover, recent preclinical studies also suggest its involvement in different physiological functions. Despite this evidence very few studies attempted to elucidate the functional role of adiponectin at the synapse. To address this question, here we investigated the effect of Adiporon, an agonist of both adiponectin receptors on synaptic transmission and LTP at Schaffer-collateral CA1 pathway. Surprisingly, increasing concentration of Adiporon correlated with lower CA1–LTP levels and paired-pulse ratio, whereas basal transmission was always preserved. Collectively, our data show that the adiponectin system, beyond its involvement in metabolic diseases, plays also a critical role in synaptic activity thereby representing a putative target for the treatment of synaptic pathologies.
AB - In the last two decades adiponectin, member of the adipokines family, gained attention because of its unique antidiabetic effects. However, the presence in the brain of adiponectin receptors and adiponectin itself raised interest because of the possible association with neuropsychiatric diseases. Indeed, clinical studies found altered concentration of adiponectin both in plasma and cerebrospinal fluid in several pathologies including depression, multiple sclerosis, Alzheimer's disease and stroke. Moreover, recent preclinical studies also suggest its involvement in different physiological functions. Despite this evidence very few studies attempted to elucidate the functional role of adiponectin at the synapse. To address this question, here we investigated the effect of Adiporon, an agonist of both adiponectin receptors on synaptic transmission and LTP at Schaffer-collateral CA1 pathway. Surprisingly, increasing concentration of Adiporon correlated with lower CA1–LTP levels and paired-pulse ratio, whereas basal transmission was always preserved. Collectively, our data show that the adiponectin system, beyond its involvement in metabolic diseases, plays also a critical role in synaptic activity thereby representing a putative target for the treatment of synaptic pathologies.
KW - adiponectin
KW - Adiporon
KW - electrophysiology
KW - hippocampus
KW - long term potentiation
KW - synaptic plasticity
UR - http://www.scopus.com/inward/record.url?scp=85013469476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85013469476&partnerID=8YFLogxK
U2 - 10.1002/syn.21964
DO - 10.1002/syn.21964
M3 - Article
C2 - 28187508
AN - SCOPUS:85013469476
VL - 71
JO - Synapse
JF - Synapse
SN - 0887-4476
IS - 5
M1 - e21964
ER -