The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus

Filippo Weisz, Sonia Piccinin, Dalila Mango, Richard Teke Ngomba, Nicola B. Mercuri, Ferdinando Nicoletti, Robert Nisticò

Research output: Contribution to journalArticlepeer-review

Abstract

In the last two decades adiponectin, member of the adipokines family, gained attention because of its unique antidiabetic effects. However, the presence in the brain of adiponectin receptors and adiponectin itself raised interest because of the possible association with neuropsychiatric diseases. Indeed, clinical studies found altered concentration of adiponectin both in plasma and cerebrospinal fluid in several pathologies including depression, multiple sclerosis, Alzheimer's disease and stroke. Moreover, recent preclinical studies also suggest its involvement in different physiological functions. Despite this evidence very few studies attempted to elucidate the functional role of adiponectin at the synapse. To address this question, here we investigated the effect of Adiporon, an agonist of both adiponectin receptors on synaptic transmission and LTP at Schaffer-collateral CA1 pathway. Surprisingly, increasing concentration of Adiporon correlated with lower CA1–LTP levels and paired-pulse ratio, whereas basal transmission was always preserved. Collectively, our data show that the adiponectin system, beyond its involvement in metabolic diseases, plays also a critical role in synaptic activity thereby representing a putative target for the treatment of synaptic pathologies.

Original languageEnglish
Article numbere21964
JournalSynapse
Volume71
Issue number5
DOIs
Publication statusPublished - May 1 2017

Keywords

  • adiponectin
  • Adiporon
  • electrophysiology
  • hippocampus
  • long term potentiation
  • synaptic plasticity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus'. Together they form a unique fingerprint.

Cite this