The role of adrenomedullin in angiogenesis

Domenico Ribatti, Beatrice Nico, Raffaella Spinazzi, Angelo Vacca, Gastone G. Nussdorfer

Research output: Contribution to journalArticlepeer-review


Adrenomedullin (AM) is a 52 amino acid peptide originally isolated from human pheochromocytoma. It was initially demonstrated to have profound effects in vascular cell biology, since AM protects endothelial cells from apoptosis, promotes angiogenesis and affects vascular tone and permeability. This review article summarizes the literature data concerning the relationship between AM and angiogenesis and describes the relationship between vascular endothelial growth factor, hypoxia and AM and tumor angiogenesis. Finally, the role of AM as a potential target of antiangiogenic therapy is discussed.

Original languageEnglish
Pages (from-to)1670-1675
Number of pages6
Issue number9
Publication statusPublished - Sep 2005


  • Adrenomedullin
  • Angiogenesis
  • HIF
  • Tumor progression
  • VEGF

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'The role of adrenomedullin in angiogenesis'. Together they form a unique fingerprint.

Cite this