The role of adrenomedullin in angiogenesis

Domenico Ribatti, Beatrice Nico, Raffaella Spinazzi, Angelo Vacca, Gastone G. Nussdorfer

Research output: Contribution to journalArticlepeer-review

Abstract

Adrenomedullin (AM) is a 52 amino acid peptide originally isolated from human pheochromocytoma. It was initially demonstrated to have profound effects in vascular cell biology, since AM protects endothelial cells from apoptosis, promotes angiogenesis and affects vascular tone and permeability. This review article summarizes the literature data concerning the relationship between AM and angiogenesis and describes the relationship between vascular endothelial growth factor, hypoxia and AM and tumor angiogenesis. Finally, the role of AM as a potential target of antiangiogenic therapy is discussed.

Original languageEnglish
Pages (from-to)1670-1675
Number of pages6
JournalPeptides
Volume26
Issue number9
DOIs
Publication statusPublished - Sep 2005

Keywords

  • Adrenomedullin
  • Angiogenesis
  • HIF
  • Tumor progression
  • VEGF

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

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