Abstract
The contractile response to ouabain and beta-adrenoceptor agonists is reduced in the senescent as compared with the adult myocardium while the development of ventricular arrhythmias is increased. In the present study, we tested the electrical and mechanical response of hearts from 3-24 month old rats receiving 15 min. infusion of ouabain (6 x 10-5 M), 5 min. of epinine (1.5 x 10-7 M) and both simultaneously. The results obtained show that aging influences negatively both positive inotropic and arrhythmogenic ouabain and epinine effects although these phenomena are more pronounced after ouabain. However, when administered simultaneously, epinine doesn't modify arrhythmogenic effect of ouabain but reduces some its hemodynamic deleterious effect.
| Original language | English |
|---|---|
| Pages (from-to) | 937-940 |
| Number of pages | 4 |
| Journal | New Trends in Arrhythmias |
| Volume | 7 |
| Issue number | 4 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
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The role of aging on ouabain- and epinine-induced ventricular arrhythmias in isolated rat heart. / Abete, P.; Ferrara, N.; Leosco, D.; Caccese, P.; Sederino, S.; Landino, P.; Rengo, F.
In: New Trends in Arrhythmias, Vol. 7, No. 4, 1991, p. 937-940.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of aging on ouabain- and epinine-induced ventricular arrhythmias in isolated rat heart
AU - Abete, P.
AU - Ferrara, N.
AU - Leosco, D.
AU - Caccese, P.
AU - Sederino, S.
AU - Landino, P.
AU - Rengo, F.
PY - 1991
Y1 - 1991
N2 - The contractile response to ouabain and beta-adrenoceptor agonists is reduced in the senescent as compared with the adult myocardium while the development of ventricular arrhythmias is increased. In the present study, we tested the electrical and mechanical response of hearts from 3-24 month old rats receiving 15 min. infusion of ouabain (6 x 10-5 M), 5 min. of epinine (1.5 x 10-7 M) and both simultaneously. The results obtained show that aging influences negatively both positive inotropic and arrhythmogenic ouabain and epinine effects although these phenomena are more pronounced after ouabain. However, when administered simultaneously, epinine doesn't modify arrhythmogenic effect of ouabain but reduces some its hemodynamic deleterious effect.
AB - The contractile response to ouabain and beta-adrenoceptor agonists is reduced in the senescent as compared with the adult myocardium while the development of ventricular arrhythmias is increased. In the present study, we tested the electrical and mechanical response of hearts from 3-24 month old rats receiving 15 min. infusion of ouabain (6 x 10-5 M), 5 min. of epinine (1.5 x 10-7 M) and both simultaneously. The results obtained show that aging influences negatively both positive inotropic and arrhythmogenic ouabain and epinine effects although these phenomena are more pronounced after ouabain. However, when administered simultaneously, epinine doesn't modify arrhythmogenic effect of ouabain but reduces some its hemodynamic deleterious effect.
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M3 - Article
VL - 7
SP - 937
EP - 940
JO - New Trends in Arrhythmias
JF - New Trends in Arrhythmias
SN - 0393-5302
IS - 4
ER -