The role of AIRE polymorphisms in melanoma

G. Conteduca, F. Ferrera, L. Pastorino, D. Fenoglio, S. Negrini, M. P. Sormani, F. Indiveri, G. Bianchi Scarrà, G. Filaci

Research output: Contribution to journalArticlepeer-review

Abstract

Polymorphisms of AIRE, a transcription factor that up-regulates intrathymic expression of tissue-specific antigens including melanoma-associated antigens (MAAs), may variably affect the selection of MAAs-specific thymocytes, generating T-cell repertoires protecting or predisposing individuals to melanoma. We found that AIRE single nucleotide polymorphisms (SNPs) rs1055311, rs1800520 and rs1800522 were significantly more frequent in healthy subjects than in melanoma patients, independently from sex, age and stages of melanoma. The presence of these SNPs was associated with increased frequency of two T-cell clonotypes specific for MAGE-1 linking their protective effect to selection/expansion of MAA-specific T cells. Interestingly, mRNA transcribed on the rs1800520 SNP showed increased free energy than the wild type suggesting that its reduced stability may be responsible for the different activity of the polymorphic AIRE molecule. This finding may contribute at identifying subjects with increased risk of developing melanoma or patients with melanoma that may take benefit from immunotherapy.

Original languageEnglish
Pages (from-to)96-104
Number of pages9
JournalClinical Immunology
Volume136
Issue number1
DOIs
Publication statusPublished - Jul 2010

Keywords

  • AIRE
  • Medullary thymic epithelial cells
  • Melanoma-associated antigens
  • Promiscuously expressed genes

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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