The role of amino acids in the modulation of cardiac metabolism during ischemia and heart failure

Giuseppe Marazzi, Salvatore Rosanio, Giuseppe Caminiti, Franceso Saverio Dioguardi, Giuseppe Mercuro

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

During ischemia and heart failure, myocardial cells suffer for chronic energy starvation resulting in metabolic and contractile dysfunction. In normal conditions fatty acids, glucose, and lactate are the principal oxidative fuels in myocardium, while amino acids serve a minor role as an oxidative fuel. However, in pathological conditions, myocardial uptake of several amino acids increases significantly as a consequence of a metabolic remodelling. Amino acids are involved in a variety of key biochemical and physiological activities, that counteract the deleterious cellular effects of reduced oxygen availability. Several amino acids are a direct source of substrate for energy production, and they modulate the activity of some enzymes involved in the glucose metabolism. They increase contractile performance both in isolated animal and human myocardium. Furthermore, amino acids improve the oxidative stress counteracting the action of radical oxygen species, being either precursors of glutathione synthesis, or of substrate of nitric oxide biosynthesis; they act on endothelial function and increase protein synthetic efficiency of myocardial cells by regulating gene expression and modulating hormonal activity. An amount of studies have demonstrated that amino acids administration, on patients with ischemic heart disease and heart failure, can improve several clinical endpoints. Here, we present an overview of the principal effects of the most experienced amino acids and of amino acid derivatives on ischemia and heart failure.

Original languageEnglish
Pages (from-to)2592-2604
Number of pages13
JournalCurrent Pharmaceutical Design
Volume14
Issue number25
DOIs
Publication statusPublished - 2008

Fingerprint

Ischemia
Heart Failure
Amino Acids
Myocardium
Glucose
Starvation
Myocardial Ischemia
Glutathione
Lactic Acid
Reactive Oxygen Species
Nitric Oxide
Oxidative Stress
Fatty Acids
Oxygen
Gene Expression
Enzymes
Proteins

Keywords

  • Amino acids
  • Cardiac metabolism
  • Heart failure
  • Myocardial ischemia

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

The role of amino acids in the modulation of cardiac metabolism during ischemia and heart failure. / Marazzi, Giuseppe; Rosanio, Salvatore; Caminiti, Giuseppe; Dioguardi, Franceso Saverio; Mercuro, Giuseppe.

In: Current Pharmaceutical Design, Vol. 14, No. 25, 2008, p. 2592-2604.

Research output: Contribution to journalArticle

Marazzi, Giuseppe ; Rosanio, Salvatore ; Caminiti, Giuseppe ; Dioguardi, Franceso Saverio ; Mercuro, Giuseppe. / The role of amino acids in the modulation of cardiac metabolism during ischemia and heart failure. In: Current Pharmaceutical Design. 2008 ; Vol. 14, No. 25. pp. 2592-2604.
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