The role of amphiregulin in breast cancer

David S. Salomon, Nicola Normanno, Fortunato Ciardiello, Ralf Brandt, Mohammed Shoyab, George J. Todaro

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Amphiregulin (AR) is an epidermal growth factor (EGF)-related peptide that operates exclusively through the EGF receptor and that can bind to heparin. AR also possesses nuclear localization sequences in the extended NH2-terminal region suggesting an additional intracellular site of action. AR mRNA and protein expression have been detected in primary human mammary epithelial cell strains, nontransformed human mammary epithelial cell lines, several human breast cancer cell lines, and primary human breast carcinomas. The frequency and levels of AR protein expression are generally higher in invasive breast carcinomas than in ductal carcinomas in situ or in normal, noninvolved mammary epithelium. In addition, AR can function as an autocrine and/or juxtacrine growth factor in human mammary epithelial cells that have been transformed by an activated c-Ha-ras proto-oncogene or by overexpression of c-erb B-2. AR expression is also enhanced by mammotrophic hormones such as estrogens and other growth factors such as EGF.

Original languageEnglish
Pages (from-to)103-114
Number of pages12
JournalBreast Cancer Research and Treatment
Volume33
Issue number2
DOIs
Publication statusPublished - Feb 1995

Fingerprint

Breast Neoplasms
Breast
Epithelial Cells
Epidermal Growth Factor
Intercellular Signaling Peptides and Proteins
Cell Line
Carcinoma, Intraductal, Noninfiltrating
ras Genes
Epidermal Growth Factor Receptor
Heparin
Amphiregulin
Estrogens
Proteins
Epithelium
Hormones
Messenger RNA
Peptides

Keywords

  • amphiregulin
  • breast tumors
  • EGF receptor
  • oncogenes
  • steroid hormones
  • transformation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Salomon, D. S., Normanno, N., Ciardiello, F., Brandt, R., Shoyab, M., & Todaro, G. J. (1995). The role of amphiregulin in breast cancer. Breast Cancer Research and Treatment, 33(2), 103-114. https://doi.org/10.1007/BF00682718

The role of amphiregulin in breast cancer. / Salomon, David S.; Normanno, Nicola; Ciardiello, Fortunato; Brandt, Ralf; Shoyab, Mohammed; Todaro, George J.

In: Breast Cancer Research and Treatment, Vol. 33, No. 2, 02.1995, p. 103-114.

Research output: Contribution to journalArticle

Salomon, DS, Normanno, N, Ciardiello, F, Brandt, R, Shoyab, M & Todaro, GJ 1995, 'The role of amphiregulin in breast cancer', Breast Cancer Research and Treatment, vol. 33, no. 2, pp. 103-114. https://doi.org/10.1007/BF00682718
Salomon DS, Normanno N, Ciardiello F, Brandt R, Shoyab M, Todaro GJ. The role of amphiregulin in breast cancer. Breast Cancer Research and Treatment. 1995 Feb;33(2):103-114. https://doi.org/10.1007/BF00682718
Salomon, David S. ; Normanno, Nicola ; Ciardiello, Fortunato ; Brandt, Ralf ; Shoyab, Mohammed ; Todaro, George J. / The role of amphiregulin in breast cancer. In: Breast Cancer Research and Treatment. 1995 ; Vol. 33, No. 2. pp. 103-114.
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