The role of antibiotics in asthma

Francesco Blasi, Sebastian L. Johnston

Research output: Contribution to journalArticle

Abstract

There is increasing evidence that atypical respiratory pathogens such as Chlamydophila pneumoniae and Mycoplasma pneumoniae may contribute to the pathogenesis of both stable asthma and asthma exacerbations. It is postulated that these organisms may contribute to inflammation in the airways possibly by activating inflammatory mechanisms in the respiratory tract. The macrolide class of antibiotics may have a part to play in the management of asthma by exerting anti-inflammatory effects on the chronically inflamed airways in addition to their anti-infective action. The ketolide antibiotics may also have similar properties. This paper discusses the role of these antibiotics in the management of asthma.

Original languageEnglish
Pages (from-to)485-493
Number of pages9
JournalInternational Journal of Antimicrobial Agents
Volume29
Issue number5
DOIs
Publication statusPublished - May 2007

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Keywords

  • Asthma
  • Asthma exacerbations
  • Atypical bacterial infection
  • Macrolide antibiotic

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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