Abstract
There is increasing evidence that atypical respiratory pathogens such as Chlamydophila pneumoniae and Mycoplasma pneumoniae may contribute to the pathogenesis of both stable asthma and asthma exacerbations. It is postulated that these organisms may contribute to inflammation in the airways possibly by activating inflammatory mechanisms in the respiratory tract. The macrolide class of antibiotics may have a part to play in the management of asthma by exerting anti-inflammatory effects on the chronically inflamed airways in addition to their anti-infective action. The ketolide antibiotics may also have similar properties. This paper discusses the role of these antibiotics in the management of asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 485-493 |
| Number of pages | 9 |
| Journal | International Journal of Antimicrobial Agents |
| Volume | 29 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 2007 |
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Keywords
- Asthma
- Asthma exacerbations
- Atypical bacterial infection
- Macrolide antibiotic
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology
- Microbiology
- Parasitology
- Virology
- Immunology and Allergy
- Infectious Diseases
Cite this
The role of antibiotics in asthma. / Blasi, Francesco; Johnston, Sebastian L.
In: International Journal of Antimicrobial Agents, Vol. 29, No. 5, 05.2007, p. 485-493.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The role of antibiotics in asthma
AU - Blasi, Francesco
AU - Johnston, Sebastian L.
PY - 2007/5
Y1 - 2007/5
N2 - There is increasing evidence that atypical respiratory pathogens such as Chlamydophila pneumoniae and Mycoplasma pneumoniae may contribute to the pathogenesis of both stable asthma and asthma exacerbations. It is postulated that these organisms may contribute to inflammation in the airways possibly by activating inflammatory mechanisms in the respiratory tract. The macrolide class of antibiotics may have a part to play in the management of asthma by exerting anti-inflammatory effects on the chronically inflamed airways in addition to their anti-infective action. The ketolide antibiotics may also have similar properties. This paper discusses the role of these antibiotics in the management of asthma.
AB - There is increasing evidence that atypical respiratory pathogens such as Chlamydophila pneumoniae and Mycoplasma pneumoniae may contribute to the pathogenesis of both stable asthma and asthma exacerbations. It is postulated that these organisms may contribute to inflammation in the airways possibly by activating inflammatory mechanisms in the respiratory tract. The macrolide class of antibiotics may have a part to play in the management of asthma by exerting anti-inflammatory effects on the chronically inflamed airways in addition to their anti-infective action. The ketolide antibiotics may also have similar properties. This paper discusses the role of these antibiotics in the management of asthma.
KW - Asthma
KW - Asthma exacerbations
KW - Atypical bacterial infection
KW - Macrolide antibiotic
UR - http://www.scopus.com/inward/record.url?scp=34147218665&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34147218665&partnerID=8YFLogxK
U2 - 10.1016/j.ijantimicag.2006.11.029
DO - 10.1016/j.ijantimicag.2006.11.029
M3 - Article
VL - 29
SP - 485
EP - 493
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
SN - 0924-8579
IS - 5
ER -