The Role of Antioxidants Supplementation in Clinical Practice: Focus on Cardiovascular Risk Factors

Vittoria Cammisotto, Cristina Nocella, Simona Bartimoccia, Valerio Sanguigni, Davide Francomano, Sebastiano Sciarretta, Daniele Pastori, Mariangela Peruzzi, Elena Cavarretta, Alessandra D'Amico, Valentina Castellani, Giacomo Frati, Roberto Carnevale, SMiLe Group

Research output: Contribution to journalReview articlepeer-review


Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.

Original languageEnglish
Pages (from-to)146
Issue number2
Publication statusPublished - Jan 20 2021


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