TY - JOUR
T1 - The Role of Antioxidants Supplementation in Clinical Practice
T2 - Focus on Cardiovascular Risk Factors
AU - Cammisotto, Vittoria
AU - Nocella, Cristina
AU - Bartimoccia, Simona
AU - Sanguigni, Valerio
AU - Francomano, Davide
AU - Sciarretta, Sebastiano
AU - Pastori, Daniele
AU - Peruzzi, Mariangela
AU - Cavarretta, Elena
AU - D'Amico, Alessandra
AU - Castellani, Valentina
AU - Frati, Giacomo
AU - Carnevale, Roberto
AU - Group, SMiLe
PY - 2021/1/20
Y1 - 2021/1/20
N2 - Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.
AB - Oxidative stress may be defined as an imbalance between reactive oxygen species (ROS) and the antioxidant system to counteract or detoxify these potentially damaging molecules. This phenomenon is a common feature of many human disorders, such as cardiovascular disease. Many of the risk factors, including smoking, hypertension, hypercholesterolemia, diabetes, and obesity, are associated with an increased risk of developing cardiovascular disease, involving an elevated oxidative stress burden (either due to enhanced ROS production or decreased antioxidant protection). There are many therapeutic options to treat oxidative stress-associated cardiovascular diseases. Numerous studies have focused on the utility of antioxidant supplementation. However, whether antioxidant supplementation has any preventive and/or therapeutic value in cardiovascular pathology is still a matter of debate. In this review, we provide a detailed description of oxidative stress biomarkers in several cardiovascular risk factors. We also discuss the clinical implications of the supplementation with several classes of antioxidants, and their potential role for protecting against cardiovascular risk factors.
U2 - 10.3390/antiox10020146
DO - 10.3390/antiox10020146
M3 - Review article
C2 - 33498338
VL - 10
SP - 146
JO - Antioxidants
JF - Antioxidants
SN - 2076-3921
IS - 2
ER -