The role of autophagy in osteoclast differentiation and bone resorption function

Azadeh Montaseri, Claudia Giampietri, Michela Rossi, Anna Riccioli, Andrea Del Fattore, Antonio Filippini

Research output: Contribution to journalReview articlepeer-review

Abstract

Autophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates unnecessary materials and provides nutrients and energy for cell survival and maintenance. The critical role of autophagy and autophagy-related proteins in osteoclast differentiation, bone resorption, and maintenance of bone homeostasis has previously been reported. Increasing evidence reveals that autophagy dysregulation leads to alteration of osteoclast function and enhanced bone loss, which is associated with the onset and progression of osteoporosis. In this review, we briefly consolidate the current state-of-the-art technology regarding the role of autophagy in osteoclast function in both physiologic and pathologic conditions to have a more general view on this issue.

Original languageEnglish
Article number1398
Pages (from-to)1-16
Number of pages16
JournalBiomolecules
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Autophagy
  • Differentiation
  • Osteoclast

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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