The role of autophagy in plasma cell ontogenesis

Niccolò Pengo, Simone Cenci

Research output: Contribution to journalArticlepeer-review

Abstract

We have identified in plasma cells a novel ATG5-dependent selective negative control on the secretory pathway, which restricts antibody production, sustaining energy metabolism. Revealing new immune functions, autophagy is required in vivo for antibody responses and to maintain the memory plasma cell compartment.

Original languageEnglish
Pages (from-to)942-944
Number of pages3
JournalAutophagy
Volume9
Issue number6
DOIs
Publication statusPublished - Jun 2013

Keywords

  • Antibody
  • Autophagy
  • Blimp-1
  • Bone marrow
  • Immunity
  • Immunological memory
  • Niche
  • Plasma cell
  • Unfolded protein response
  • XBP-1

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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