Abstract
Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac homeostasis and function. Autophagy preserves cardiac structure and function under baseline conditions and is activated during stress, limiting damage under most conditions. It reduces injury and preserves cardiac function during ischemia. It also reduces chronic ischemic remodeling and mediates the cardiac adaptation to pressure overload by restricting misfolded protein accumulation, mitochondrial dysfunction, and oxidative stress. Impairment of autophagy is involved in the development of diabetes and aging-induced cardiac abnormalities. Autophagy defects contribute to the development of cardiac proteinopathy and doxorubicin-induced cardiomyopathy. However, massive activation of autophagy may be detrimental for the heart in certain stress conditions, such as reperfusion injury. In this review, we discuss recent evidence supporting the important role of autophagy and mitophagy in the regulation of cardiac homeostasis and adaptation to stress.
| Original language | English |
|---|---|
| Pages (from-to) | 1-26 |
| Number of pages | 26 |
| Journal | Annual Review of Physiology |
| Volume | 80 |
| DOIs | |
| Publication status | Published - Feb 10 2018 |
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Keywords
- Autophagy
- Autosis
- Lysosome
- Mitophagy
- Protein quality control
- Proteinopathy
ASJC Scopus subject areas
- Physiology
Cite this
The Role of Autophagy in the Heart. / Sciarretta, Sebastiano; Maejima, Yasuhiro; Zablocki, Daniela; Sadoshima, Junichi.
In: Annual Review of Physiology, Vol. 80, 10.02.2018, p. 1-26.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The Role of Autophagy in the Heart
AU - Sciarretta, Sebastiano
AU - Maejima, Yasuhiro
AU - Zablocki, Daniela
AU - Sadoshima, Junichi
PY - 2018/2/10
Y1 - 2018/2/10
N2 - Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac homeostasis and function. Autophagy preserves cardiac structure and function under baseline conditions and is activated during stress, limiting damage under most conditions. It reduces injury and preserves cardiac function during ischemia. It also reduces chronic ischemic remodeling and mediates the cardiac adaptation to pressure overload by restricting misfolded protein accumulation, mitochondrial dysfunction, and oxidative stress. Impairment of autophagy is involved in the development of diabetes and aging-induced cardiac abnormalities. Autophagy defects contribute to the development of cardiac proteinopathy and doxorubicin-induced cardiomyopathy. However, massive activation of autophagy may be detrimental for the heart in certain stress conditions, such as reperfusion injury. In this review, we discuss recent evidence supporting the important role of autophagy and mitophagy in the regulation of cardiac homeostasis and adaptation to stress.
AB - Autophagy is an evolutionarily conserved mechanism by which cytoplasmic elements are degraded intracellularly. Autophagy has also emerged as a major regulator of cardiac homeostasis and function. Autophagy preserves cardiac structure and function under baseline conditions and is activated during stress, limiting damage under most conditions. It reduces injury and preserves cardiac function during ischemia. It also reduces chronic ischemic remodeling and mediates the cardiac adaptation to pressure overload by restricting misfolded protein accumulation, mitochondrial dysfunction, and oxidative stress. Impairment of autophagy is involved in the development of diabetes and aging-induced cardiac abnormalities. Autophagy defects contribute to the development of cardiac proteinopathy and doxorubicin-induced cardiomyopathy. However, massive activation of autophagy may be detrimental for the heart in certain stress conditions, such as reperfusion injury. In this review, we discuss recent evidence supporting the important role of autophagy and mitophagy in the regulation of cardiac homeostasis and adaptation to stress.
KW - Autophagy
KW - Autosis
KW - Lysosome
KW - Mitophagy
KW - Protein quality control
KW - Proteinopathy
UR - http://www.scopus.com/inward/record.url?scp=85041929758&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041929758&partnerID=8YFLogxK
U2 - 10.1146/annurev-physiol-021317-121427
DO - 10.1146/annurev-physiol-021317-121427
M3 - Review article
VL - 80
SP - 1
EP - 26
JO - Annual Review of Physiology
JF - Annual Review of Physiology
SN - 0066-4278
ER -