The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy

Antonio Di Biagio, Stefano Rusconi, Angela Marzocchetti, Alessio Signori, Irene Schiavetti, Bianca Bruzzone, Laura Monno, Grazia Punzi, Maria Grazia Colao, Giovanni Penco, Maurizio Zazzi, Andrea De Luca, Andrea Giacometti, Luca Butini, Romana Del Gobbo, Patrizia Bagnarelli, Danilo Tacconi, Giovanni Corbelli, Stefania Zanussi, Franco MaggioloAnnapaola Callegaro, Leonardo Calza, Maria Carla Re, Raffaele Pristerà, Paola Turconi, Antonella Mandas, Alessandra Pozzo, Nuccia Simeone, Sauro Tini, Alessia Zoncada, Elisabetta Paolini, Giorgio Amadio, Laura Sighinolfi, Giuliano Zuccati, Massimo Morfini, Roberto Manetti, Paola Corsi, Luisa Galli, Massimo Di Pietro, Filippo Bartalesi, Grazia Colao, Andrea Tosti, Maurizio Setti, Michele Trezzi, Paolo Bonfanti, Riccardo Pardelli, Irene Arcidiacono, Alberto Degiuli, Michele De Gennaro, Alessandro Chiodera, Alfredo Scalzini, Loredana Palvarini, Paolo Almi, Giovanni Todaro, Paola Cicconi, Maria Rita Gismondo, Valeria Micheli, Maria Luisa Biondi, Nicola Gianotti, Amedeo Capetti, Paola Meraviglia, Enzo Boeri, Cristina Mussini, Monica Pecorari, Alessandro Soria, Sergio Malandrin, Maurizio Santirocchi, Diego Brustia, Paolo Ravanini, Federico Dal Bello, Nino Romano, Maurizio Mineo, Salvatrice Mancuso, Carlo Calzetti, Renato Maserati, Gaetano Filice, Fausto Baldanti, Daniela Francisci, Giustino Parruti, Ennio Polilli, Daria Sacchini, Chiara Martinelli, Rita Consolini, Linda Vatteroni, Angela Vivarelli, Alessandro Nerli, Lucia Lenzi, Giacomo Magnani, Patrizia Ortolani, Massimo Andreoni, Guido Palamara, Caterina Fimiani, Lucia Palmisano, Simona Di Gaimbenedetto, Manuela Colafigli, Vincenzo Vullo, Ombretta Turriziani, Marco Montano, Cataldo Senatore, Chiara Dentone, Angela Gonnelli, Michele Palumbo, Valeria Ghisetti, Stefano Bonora, Palma Delle Foglie, Cristina Rossi, Paolo Grossi, Elena Seminari, Federica Poletti, Vincenzo Mondino, Marina Malena

Research output: Contribution to journalArticlepeer-review

Abstract

The factors influencing virological response to first-line combined antiretroviral therapy (cART) in an Italian cohort of HIV-1-infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first-line cART between 2001 and 2011 and who had at least one follow-up of HIV-1 RNA. The primary endpoint was virological success, defined as the first viral load + cell count, viral subtype, and type of NRTI backbone employed, independent predictors of virological success were higher baseline viral load (≥500,000 vs. 100,000 copies/ml, virologic success was only associated with the use of integrase inhibitors in the first cART regimen. Independent predictors of immunological success were baseline CD4+ cell count and wGSS

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalJournal of Medical Virology
Volume86
Issue number10
DOIs
Publication statusPublished - 2014

Keywords

  • CD4
  • Drug regimen
  • Drug resistance
  • HIV-1 RNA
  • N(n)RTI backbone
  • WGSS

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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