The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy

Antonio Di Biagio; Stefano Rusconi; Angela Marzocchetti; Alessio Signori; Irene Schiavetti; Bianca Bruzzone; Laura Monno; Grazia Punzi; Maria Grazia Colao; Giovanni Penco; Maurizio Zazzi; Andrea De Luca; Andrea Giacometti; Luca Butini; Romana Del Gobbo; Patrizia Bagnarelli; Danilo Tacconi; Giovanni Corbelli; Stefania Zanussi; Franco Maggiolo; Annapaola Callegaro; Leonardo Calza; Maria Carla Re; Raffaele Pristerà; Paola Turconi; Antonella Mandas; Alessandra Pozzo; Nuccia Simeone; Sauro Tini; Alessia Zoncada; Elisabetta Paolini; Giorgio Amadio; Laura Sighinolfi; Giuliano Zuccati; Massimo Morfini; Roberto Manetti; Paola Corsi; Luisa Galli; Massimo Di Pietro; Filippo Bartalesi; Grazia Colao; Andrea Tosti; Maurizio Setti; Michele Trezzi; Paolo Bonfanti; Riccardo Pardelli; Irene Arcidiacono; Alberto Degiuli; Michele De Gennaro; Alessandro Chiodera; Alfredo Scalzini; Loredana Palvarini; Paolo Almi; Giovanni Todaro; Paola Cicconi; Maria Rita Gismondo; Valeria Micheli; Maria Luisa Biondi; Nicola Gianotti; Amedeo Capetti; Paola Meraviglia; Enzo Boeri; Cristina Mussini; Monica Pecorari; Alessandro Soria; Sergio Malandrin; Maurizio Santirocchi; Diego Brustia; Paolo Ravanini; Federico Dal Bello; Nino Romano; Maurizio Mineo; Salvatrice Mancuso; Carlo Calzetti; Renato Maserati; Gaetano Filice; Fausto Baldanti; Daniela Francisci; Giustino Parruti; Ennio Polilli; Daria Sacchini; Chiara Martinelli; Rita Consolini; Linda Vatteroni; Angela Vivarelli; Alessandro Nerli; Lucia Lenzi; Giacomo Magnani; Patrizia Ortolani; Massimo Andreoni; Guido Palamara; Caterina Fimiani; Lucia Palmisano; Simona Di Gaimbenedetto; Manuela Colafigli; Vincenzo Vullo; Ombretta Turriziani; Marco Montano; Cataldo Senatore; Chiara Dentone; Angela Gonnelli; Michele Palumbo; Valeria Ghisetti; Stefano Bonora; Palma Delle Foglie; Cristina Rossi; Paolo Grossi; Elena Seminari; Federica Poletti; Vincenzo Mondino; Marina Malena

doi:10.1002/jmv.24017

The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy

Antonio Di Biagio, Stefano Rusconi, Angela Marzocchetti, Alessio Signori, Irene Schiavetti, Bianca Bruzzone, Laura Monno, Grazia Punzi, Maria Grazia Colao, Giovanni Penco, Maurizio Zazzi, Andrea De Luca, Andrea Giacometti, Luca Butini, Romana Del Gobbo, Patrizia Bagnarelli, Danilo Tacconi, Giovanni Corbelli, Stefania Zanussi, Franco MaggioloAnnapaola Callegaro, Leonardo Calza, Maria Carla Re, Raffaele Pristerà, Paola Turconi, Antonella Mandas, Alessandra Pozzo, Nuccia Simeone, Sauro Tini, Alessia Zoncada, Elisabetta Paolini, Giorgio Amadio, Laura Sighinolfi, Giuliano Zuccati, Massimo Morfini, Roberto Manetti, Paola Corsi, Luisa Galli, Massimo Di Pietro, Filippo Bartalesi, Grazia Colao, Andrea Tosti, Maurizio Setti, Michele Trezzi, Paolo Bonfanti, Riccardo Pardelli, Irene Arcidiacono, Alberto Degiuli, Michele De Gennaro, Alessandro Chiodera, Alfredo Scalzini, Loredana Palvarini, Paolo Almi, Giovanni Todaro, Paola Cicconi, Maria Rita Gismondo, Valeria Micheli, Maria Luisa Biondi, Nicola Gianotti, Amedeo Capetti, Paola Meraviglia, Enzo Boeri, Cristina Mussini, Monica Pecorari, Alessandro Soria, Sergio Malandrin, Maurizio Santirocchi, Diego Brustia, Paolo Ravanini, Federico Dal Bello, Nino Romano, Maurizio Mineo, Salvatrice Mancuso, Carlo Calzetti, Renato Maserati, Gaetano Filice, Fausto Baldanti, Daniela Francisci, Giustino Parruti, Ennio Polilli, Daria Sacchini, Chiara Martinelli, Rita Consolini, Linda Vatteroni, Angela Vivarelli, Alessandro Nerli, Lucia Lenzi, Giacomo Magnani, Patrizia Ortolani, Massimo Andreoni, Guido Palamara, Caterina Fimiani, Lucia Palmisano, Simona Di Gaimbenedetto, Manuela Colafigli, Vincenzo Vullo, Ombretta Turriziani, Marco Montano, Cataldo Senatore, Chiara Dentone, Angela Gonnelli, Michele Palumbo, Valeria Ghisetti, Stefano Bonora, Palma Delle Foglie, Cristina Rossi, Paolo Grossi, Elena Seminari, Federica Poletti, Vincenzo Mondino, Marina Malena

Research output: Contribution to journal › Article › peer-review

Abstract

The factors influencing virological response to first-line combined antiretroviral therapy (cART) in an Italian cohort of HIV-1-infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first-line cART between 2001 and 2011 and who had at least one follow-up of HIV-1 RNA. The primary endpoint was virological success, defined as the first viral load + cell count, viral subtype, and type of NRTI backbone employed, independent predictors of virological success were higher baseline viral load (≥500,000 vs. 100,000 copies/ml, virologic success was only associated with the use of integrase inhibitors in the first cART regimen. Independent predictors of immunological success were baseline CD4⁺ cell count and wGSS

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Journal of Medical Virology
Volume	86
Issue number	10
DOIs	https://doi.org/10.1002/jmv.24017
Publication status	Published - 2014

Keywords

CD4
Drug regimen
Drug resistance
HIV-1 RNA
N(n)RTI backbone
WGSS

ASJC Scopus subject areas

Virology
Infectious Diseases

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10.1002/jmv.24017

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Di Biagio, A., Rusconi, S., Marzocchetti, A., Signori, A., Schiavetti, I., Bruzzone, B., Monno, L., Punzi, G., Colao, M. G., Penco, G., Zazzi, M., De Luca, A., Giacometti, A., Butini, L., Del Gobbo, R., Bagnarelli, P., Tacconi, D., Corbelli, G., Zanussi, S., ... Malena, M. (2014). The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy. Journal of Medical Virology, 86(10), 1-8. https://doi.org/10.1002/jmv.24017

The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy. / Di Biagio, Antonio; Rusconi, Stefano; Marzocchetti, Angela; Signori, Alessio; Schiavetti, Irene; Bruzzone, Bianca; Monno, Laura; Punzi, Grazia; Colao, Maria Grazia; Penco, Giovanni; Zazzi, Maurizio; De Luca, Andrea; Giacometti, Andrea; Butini, Luca; Del Gobbo, Romana; Bagnarelli, Patrizia; Tacconi, Danilo; Corbelli, Giovanni; Zanussi, Stefania; Maggiolo, Franco; Callegaro, Annapaola; Calza, Leonardo; Re, Maria Carla; Pristerà, Raffaele; Turconi, Paola; Mandas, Antonella; Pozzo, Alessandra; Simeone, Nuccia; Tini, Sauro; Zoncada, Alessia; Paolini, Elisabetta; Amadio, Giorgio; Sighinolfi, Laura; Zuccati, Giuliano; Morfini, Massimo; Manetti, Roberto; Corsi, Paola; Galli, Luisa; Di Pietro, Massimo; Bartalesi, Filippo; Colao, Grazia; Tosti, Andrea; Setti, Maurizio; Trezzi, Michele; Bonfanti, Paolo; Pardelli, Riccardo; Arcidiacono, Irene; Degiuli, Alberto; De Gennaro, Michele; Chiodera, Alessandro; Scalzini, Alfredo; Palvarini, Loredana; Almi, Paolo; Todaro, Giovanni; Cicconi, Paola; Gismondo, Maria Rita; Micheli, Valeria; Biondi, Maria Luisa; Gianotti, Nicola; Capetti, Amedeo; Meraviglia, Paola; Boeri, Enzo; Mussini, Cristina; Pecorari, Monica; Soria, Alessandro; Malandrin, Sergio; Santirocchi, Maurizio; Brustia, Diego; Ravanini, Paolo; Dal Bello, Federico; Romano, Nino; Mineo, Maurizio; Mancuso, Salvatrice; Calzetti, Carlo; Maserati, Renato ; Filice, Gaetano ; Baldanti, Fausto; Francisci, Daniela; Parruti, Giustino; Polilli, Ennio; Sacchini, Daria; Martinelli, Chiara; Consolini, Rita; Vatteroni, Linda; Vivarelli, Angela; Nerli, Alessandro; Lenzi, Lucia; Magnani, Giacomo; Ortolani, Patrizia; Andreoni, Massimo; Palamara, Guido; Fimiani, Caterina; Palmisano, Lucia; Di Gaimbenedetto, Simona; Colafigli, Manuela; Vullo, Vincenzo; Turriziani, Ombretta; Montano, Marco; Senatore, Cataldo; Dentone, Chiara; Gonnelli, Angela; Palumbo, Michele; Ghisetti, Valeria; Bonora, Stefano; Foglie, Palma Delle; Rossi, Cristina; Grossi, Paolo; Seminari, Elena; Poletti, Federica; Mondino, Vincenzo; Malena, Marina.

In: Journal of Medical Virology, Vol. 86, No. 10, 2014, p. 1-8.

Research output: Contribution to journal › Article › peer-review

Di Biagio, A, Rusconi, S, Marzocchetti, A, Signori, A, Schiavetti, I, Bruzzone, B, Monno, L, Punzi, G, Colao, MG, Penco, G, Zazzi, M, De Luca, A, Giacometti, A, Butini, L, Del Gobbo, R, Bagnarelli, P, Tacconi, D, Corbelli, G, Zanussi, S, Maggiolo, F, Callegaro, A, Calza, L, Re, MC, Pristerà, R, Turconi, P, Mandas, A, Pozzo, A, Simeone, N, Tini, S, Zoncada, A, Paolini, E, Amadio, G, Sighinolfi, L, Zuccati, G, Morfini, M, Manetti, R, Corsi, P, Galli, L, Di Pietro, M, Bartalesi, F, Colao, G, Tosti, A, Setti, M, Trezzi, M, Bonfanti, P, Pardelli, R, Arcidiacono, I, Degiuli, A, De Gennaro, M, Chiodera, A, Scalzini, A, Palvarini, L, Almi, P, Todaro, G, Cicconi, P, Gismondo, MR, Micheli, V, Biondi, ML, Gianotti, N, Capetti, A, Meraviglia, P, Boeri, E, Mussini, C, Pecorari, M, Soria, A, Malandrin, S, Santirocchi, M, Brustia, D, Ravanini, P, Dal Bello, F, Romano, N, Mineo, M, Mancuso, S, Calzetti, C, Maserati, R , Filice, G , Baldanti, F, Francisci, D, Parruti, G, Polilli, E, Sacchini, D, Martinelli, C, Consolini, R, Vatteroni, L, Vivarelli, A, Nerli, A, Lenzi, L, Magnani, G, Ortolani, P, Andreoni, M, Palamara, G, Fimiani, C, Palmisano, L, Di Gaimbenedetto, S, Colafigli, M, Vullo, V, Turriziani, O, Montano, M, Senatore, C, Dentone, C, Gonnelli, A, Palumbo, M, Ghisetti, V, Bonora, S, Foglie, PD, Rossi, C, Grossi, P, Seminari, E, Poletti, F, Mondino, V & Malena, M 2014, 'The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy', Journal of Medical Virology, vol. 86, no. 10, pp. 1-8. https://doi.org/10.1002/jmv.24017

Di Biagio, Antonio ; Rusconi, Stefano ; Marzocchetti, Angela ; Signori, Alessio ; Schiavetti, Irene ; Bruzzone, Bianca ; Monno, Laura ; Punzi, Grazia ; Colao, Maria Grazia ; Penco, Giovanni ; Zazzi, Maurizio ; De Luca, Andrea ; Giacometti, Andrea ; Butini, Luca ; Del Gobbo, Romana ; Bagnarelli, Patrizia ; Tacconi, Danilo ; Corbelli, Giovanni ; Zanussi, Stefania ; Maggiolo, Franco ; Callegaro, Annapaola ; Calza, Leonardo ; Re, Maria Carla ; Pristerà, Raffaele ; Turconi, Paola ; Mandas, Antonella ; Pozzo, Alessandra ; Simeone, Nuccia ; Tini, Sauro ; Zoncada, Alessia ; Paolini, Elisabetta ; Amadio, Giorgio ; Sighinolfi, Laura ; Zuccati, Giuliano ; Morfini, Massimo ; Manetti, Roberto ; Corsi, Paola ; Galli, Luisa ; Di Pietro, Massimo ; Bartalesi, Filippo ; Colao, Grazia ; Tosti, Andrea ; Setti, Maurizio ; Trezzi, Michele ; Bonfanti, Paolo ; Pardelli, Riccardo ; Arcidiacono, Irene ; Degiuli, Alberto ; De Gennaro, Michele ; Chiodera, Alessandro ; Scalzini, Alfredo ; Palvarini, Loredana ; Almi, Paolo ; Todaro, Giovanni ; Cicconi, Paola ; Gismondo, Maria Rita ; Micheli, Valeria ; Biondi, Maria Luisa ; Gianotti, Nicola ; Capetti, Amedeo ; Meraviglia, Paola ; Boeri, Enzo ; Mussini, Cristina ; Pecorari, Monica ; Soria, Alessandro ; Malandrin, Sergio ; Santirocchi, Maurizio ; Brustia, Diego ; Ravanini, Paolo ; Dal Bello, Federico ; Romano, Nino ; Mineo, Maurizio ; Mancuso, Salvatrice ; Calzetti, Carlo ; Maserati, Renato ; Filice, Gaetano ; Baldanti, Fausto ; Francisci, Daniela ; Parruti, Giustino ; Polilli, Ennio ; Sacchini, Daria ; Martinelli, Chiara ; Consolini, Rita ; Vatteroni, Linda ; Vivarelli, Angela ; Nerli, Alessandro ; Lenzi, Lucia ; Magnani, Giacomo ; Ortolani, Patrizia ; Andreoni, Massimo ; Palamara, Guido ; Fimiani, Caterina ; Palmisano, Lucia ; Di Gaimbenedetto, Simona ; Colafigli, Manuela ; Vullo, Vincenzo ; Turriziani, Ombretta ; Montano, Marco ; Senatore, Cataldo ; Dentone, Chiara ; Gonnelli, Angela ; Palumbo, Michele ; Ghisetti, Valeria ; Bonora, Stefano ; Foglie, Palma Delle ; Rossi, Cristina ; Grossi, Paolo ; Seminari, Elena ; Poletti, Federica ; Mondino, Vincenzo ; Malena, Marina. / The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy. In: Journal of Medical Virology. 2014 ; Vol. 86, No. 10. pp. 1-8.

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abstract = "The factors influencing virological response to first-line combined antiretroviral therapy (cART) in an Italian cohort of HIV-1-infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first-line cART between 2001 and 2011 and who had at least one follow-up of HIV-1 RNA. The primary endpoint was virological success, defined as the first viral load + cell count, viral subtype, and type of NRTI backbone employed, independent predictors of virological success were higher baseline viral load (≥500,000 vs. 100,000 copies/ml, virologic success was only associated with the use of integrase inhibitors in the first cART regimen. Independent predictors of immunological success were baseline CD4+ cell count and wGSS ",

keywords = "CD4, Drug regimen, Drug resistance, HIV-1 RNA, N(n)RTI backbone, WGSS",

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T1 - The role of baseline HIV-1 RNA, drug resistance, and regimen type as determinants of response to first-line antiretroviral therapy

AU - Di Biagio, Antonio

AU - Rusconi, Stefano

AU - Marzocchetti, Angela

AU - Signori, Alessio

AU - Schiavetti, Irene

AU - Bruzzone, Bianca

AU - Monno, Laura

AU - Punzi, Grazia

AU - Colao, Maria Grazia

AU - Penco, Giovanni

AU - Zazzi, Maurizio

AU - De Luca, Andrea

AU - Giacometti, Andrea

AU - Butini, Luca

AU - Del Gobbo, Romana

AU - Bagnarelli, Patrizia

AU - Tacconi, Danilo

AU - Corbelli, Giovanni

AU - Zanussi, Stefania

AU - Maggiolo, Franco

AU - Callegaro, Annapaola

AU - Calza, Leonardo

AU - Re, Maria Carla

AU - Pristerà, Raffaele

AU - Turconi, Paola

AU - Mandas, Antonella

AU - Pozzo, Alessandra

AU - Simeone, Nuccia

AU - Tini, Sauro

AU - Zoncada, Alessia

AU - Paolini, Elisabetta

AU - Amadio, Giorgio

AU - Sighinolfi, Laura

AU - Zuccati, Giuliano

AU - Morfini, Massimo

AU - Manetti, Roberto

AU - Corsi, Paola

AU - Galli, Luisa

AU - Di Pietro, Massimo

AU - Bartalesi, Filippo

AU - Colao, Grazia

AU - Tosti, Andrea

AU - Setti, Maurizio

AU - Trezzi, Michele

AU - Bonfanti, Paolo

AU - Pardelli, Riccardo

AU - Arcidiacono, Irene

AU - Degiuli, Alberto

AU - De Gennaro, Michele

AU - Chiodera, Alessandro

AU - Scalzini, Alfredo

AU - Palvarini, Loredana

AU - Almi, Paolo

AU - Todaro, Giovanni

AU - Cicconi, Paola

AU - Gismondo, Maria Rita

AU - Micheli, Valeria

AU - Biondi, Maria Luisa

AU - Gianotti, Nicola

AU - Capetti, Amedeo

AU - Meraviglia, Paola

AU - Boeri, Enzo

AU - Mussini, Cristina

AU - Pecorari, Monica

AU - Soria, Alessandro

AU - Malandrin, Sergio

AU - Santirocchi, Maurizio

AU - Brustia, Diego

AU - Ravanini, Paolo

AU - Dal Bello, Federico

AU - Romano, Nino

AU - Mineo, Maurizio

AU - Mancuso, Salvatrice

AU - Calzetti, Carlo

AU - Maserati, Renato

AU - Filice, Gaetano

AU - Baldanti, Fausto

AU - Francisci, Daniela

AU - Parruti, Giustino

AU - Polilli, Ennio

AU - Sacchini, Daria

AU - Martinelli, Chiara

AU - Consolini, Rita

AU - Vatteroni, Linda

AU - Vivarelli, Angela

AU - Nerli, Alessandro

AU - Lenzi, Lucia

AU - Magnani, Giacomo

AU - Ortolani, Patrizia

AU - Andreoni, Massimo

AU - Palamara, Guido

AU - Fimiani, Caterina

AU - Palmisano, Lucia

AU - Di Gaimbenedetto, Simona

AU - Colafigli, Manuela

AU - Vullo, Vincenzo

AU - Turriziani, Ombretta

AU - Montano, Marco

AU - Senatore, Cataldo

AU - Dentone, Chiara

AU - Gonnelli, Angela

AU - Palumbo, Michele

AU - Ghisetti, Valeria

AU - Bonora, Stefano

AU - Foglie, Palma Delle

AU - Rossi, Cristina

AU - Grossi, Paolo

AU - Seminari, Elena

AU - Poletti, Federica

AU - Mondino, Vincenzo

AU - Malena, Marina

PY - 2014

Y1 - 2014

N2 - The factors influencing virological response to first-line combined antiretroviral therapy (cART) in an Italian cohort of HIV-1-infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first-line cART between 2001 and 2011 and who had at least one follow-up of HIV-1 RNA. The primary endpoint was virological success, defined as the first viral load + cell count, viral subtype, and type of NRTI backbone employed, independent predictors of virological success were higher baseline viral load (≥500,000 vs. 100,000 copies/ml, virologic success was only associated with the use of integrase inhibitors in the first cART regimen. Independent predictors of immunological success were baseline CD4+ cell count and wGSS

AB - The factors influencing virological response to first-line combined antiretroviral therapy (cART) in an Italian cohort of HIV-1-infected patients were examined. Eligible patients were those enrolled in a national prospective observational cohort (Antiretroviral Resistance Cohort Analysis), starting first-line cART between 2001 and 2011 and who had at least one follow-up of HIV-1 RNA. The primary endpoint was virological success, defined as the first viral load + cell count, viral subtype, and type of NRTI backbone employed, independent predictors of virological success were higher baseline viral load (≥500,000 vs. 100,000 copies/ml, virologic success was only associated with the use of integrase inhibitors in the first cART regimen. Independent predictors of immunological success were baseline CD4+ cell count and wGSS

KW - CD4

KW - Drug regimen

KW - Drug resistance

KW - HIV-1 RNA

KW - N(n)RTI backbone

KW - WGSS

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DO - 10.1002/jmv.24017

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