The role of bisphosphonates in childhood diseases

Giorgio Attina, Stefano Mastrangelo, Antonio Ruggiero

Research output: Contribution to journalArticlepeer-review


Bisphosphonates have found in recent years an increasingly wide application in adult neoplastic diseases and osteoporosis. Their mechanism of action is based on the inhibition of bone turnover favouring, in particular, the mineralization and the reduction of the frequency of the remodelling cycles. The fields of application of bisphosphonates in paediatric age are constantly evolving although new trials are needed to define the schedule of administration and their long-term side effects.

Original languageEnglish
Pages (from-to)1501-1507
Number of pages7
JournalBiomedical and Pharmacology Journal
Issue number3
Publication statusPublished - 2021


  • Bisphosphonates
  • Bone
  • Children

ASJC Scopus subject areas

  • Pharmacology


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