The role of calprotectin in predicting endoscopic post-surgical recurrence in asymptomatic Crohn's disease: A comparison with ultrasound

A. Orlando, I. Modesto, F. Castiglione, L. Scala, D. Scimeca, A. Rispo, S. Teresi, F. Mocciaro, V. Criscuoli, C. Marrone, P. Platania, T. De Falco, S. Maisano, N. Nicoli, M. Cottone

Research output: Contribution to journalArticle

Abstract

Background and objectives: Faecal calprotectin is predictive of clinical relapse in inflammatory bowel disease and ultrasound is sensitive in detecting its post-surgical recurrence. However, no data regarding the role of calprotectin in predicting post-surgical recurrence in asymptomatic Crohn's disease are available. The aim of th is study was to prospectively evaluate the role of calprotectin as a predictive marker for one year post-surgical endoscopic recurrence in comparison with ultrasound in patients with asymptomatic Crohn's disease. Material and methods: We consecutively en listed 50 patients who had undergone a resection for Crohn's disease. Faecal calprotectin was analysed and ultrasound were performed at the third month, and a colonoscopy after one year. The sensitivity and specificity of these two techniques were evaluated using endoscopic findings as a golden standard. A Receiver Operator Curve (ROC) curve was plotted, in order to identify the best-cut off value for calprotectin. Results: 39 out of 50 patients were evaluated by performing a colonoscopy after one year; 19 patients had an endoscopic recurrence after one year. Calprotectin sensitivity and specificity were calculated for 5 different cut-off values; the best cut-off value for calprotectin sensitivity (63%) and specificity (75%) was > 200 mg/L. The US sensitivity and specificity at the third month were 26% and 90% respectively. Conclusions: When performed three months after surgery ul trasound is more specific than calprotectin in predicting endoscopic recurrence. Faecal calprotectin at a dosage > 200 mg/L seems to have a better sensitivity than ultrasound. Values of calprotectin > 200 mg can be an indication to colonoscopy in the group of patients with negative ultrasound in order to detect early recurrence.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalEuropean Review for Medical and Pharmacological Sciences
Volume10
Issue number1
Publication statusPublished - Jan 2006

Keywords

  • Calprotectin
  • Crohn's disease
  • Recurrence
  • Ultrasound

ASJC Scopus subject areas

  • Pharmacology

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  • Cite this

    Orlando, A., Modesto, I., Castiglione, F., Scala, L., Scimeca, D., Rispo, A., Teresi, S., Mocciaro, F., Criscuoli, V., Marrone, C., Platania, P., De Falco, T., Maisano, S., Nicoli, N., & Cottone, M. (2006). The role of calprotectin in predicting endoscopic post-surgical recurrence in asymptomatic Crohn's disease: A comparison with ultrasound. European Review for Medical and Pharmacological Sciences, 10(1), 17-22.