The role of cancer Biomarkers in HIV infected hosts

Domenico Galati, Serena Zanotta

Research output: Contribution to journalReview article

Abstract

A higher incidence of cancer has been observed in Human Immunodeficiency Virus (HIV) infected individuals as compared with healthy people of the same age. A complex relationship between HIV-induced immune suppression, chronic antigenic stimulation, and oncogenic virus co-infections may promote carcinogenesis and increase the risk of developing tumors in these patients. Cancers in HIV subjects include the AIDS-defining malignancies (ADMs) and other non-AIDS-defining malignancies (NADMs). Antiretroviral therapy has reduced the incidence of ADMs whereas a concurrent increase of NADMs was observed in the last years. Biomarkers are measurable parameters, characterizing normal or pathogenic processes, which could provide a high potential for risk evaluation and diagnosis of patients. Therefore, the early detection of cancer biomarkers in HIV-positive subjects would be useful to identify patients at most risk of tumor disease development. This review will focus principally on the risk assessment and diagnostic role of several biomarkers of malignancy in HIV patients including cellular and viral biomarkers, cytokines, immune activation molecules and genetic polymorphisms.

Original languageEnglish
Pages (from-to)2333-2349
Number of pages17
JournalCurrent Medicinal Chemistry
Volume23
Issue number22
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • AIDS malignancies
  • Cancer biomarkers
  • Cancer HIV
  • Hodgkin lymphoma
  • Non AIDS malignancies
  • Non hodgkin lymphoma

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Fingerprint Dive into the research topics of 'The role of cancer Biomarkers in HIV infected hosts'. Together they form a unique fingerprint.

  • Cite this