Abstract
| Original language | English |
|---|---|
| Journal | European Respiratory Review |
| Volume | 27 |
| Issue number | 148 |
| DOIs | |
| Publication status | Published - May 2 2018 |
Keywords
- cardiopulmonary exercise test
- cardiovascular parameters
- drug targeting
- exercise
- human
- pathophysiology
- patient care
- practice guideline
- prognosis
- pulmonary hypertension
- respiratory tract parameters
- Review
- arterial pressure
- exercise test
- exercise tolerance
- lung
- predictive value
- pulmonary artery
- Arterial Pressure
- Exercise Test
- Exercise Tolerance
- Humans
- Hypertension, Pulmonary
- Lung
- Predictive Value of Tests
- Prognosis
- Pulmonary Artery
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The role of cardiopulmonary exercise tests in pulmonary arterial hypertension. / Farina, S.; Correale, M.; Bruno, N.; Paolillo, S.; Salvioni, E.; Badagliacca, R.; Agostoni, P.; Cardiology, Right and Left Heart Failure Study Group of the Italian Society of.
In: European Respiratory Review, Vol. 27, No. 148, 02.05.2018.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The role of cardiopulmonary exercise tests in pulmonary arterial hypertension
AU - Farina, S.
AU - Correale, M.
AU - Bruno, N.
AU - Paolillo, S.
AU - Salvioni, E.
AU - Badagliacca, R.
AU - Agostoni, P.
AU - Cardiology, Right and Left Heart Failure Study Group of the Italian Society of
N1 - Export Date: 25 January 2019 CODEN: EREWE Correspondence Address: Agostoni, P.; Dept of Cardiovascular Sciences, Centro Cardiologico Monzino, IRCCS, Via Parea 4, Italy; email: piergiuseppe.agostoni@ccfm.it References: Seeger, W., Adir, Y., Barbera, J.A., Pulmonary hypertension in chronic lung diseases (2013) J am Coll Cardiol, 62, pp. D109-D116; Hatano, S., Strasser, T., (1975) Primary Pulmonary Hypertension: Report on a WHO Meeting. Geneva, , http://apps.who.int/iris/bitstream/handle/10665/39094/9241560444_eng.pdf;jsessionid=4DEFB2B71BEDF5870191F1AE420B7EDF?sequence=1, World Health Organization; Barst, R.J., Rubin, L.J., Long, W.A., A comparison of continuous intravenous epoprostenol (Prostacyclin) with conventional therapy for primary pulmonary hypertension (1996) N Engl J Med, 334, pp. 296-301; Rubin, L.J., Mendoza, J., Hood, M., Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (Epoprostenol). Results of a randomized trial (1990) Ann Intern Med, 112, pp. 485-491; Rich, S., (1998) Executive Summary from the World Symposium on Primary Pulmonary Hypertension, , 1998, World Symposium on Primary Pulmonary Hypertension, 1998, September 6–10, Evian, France, cosponsored by the World Health Organization; Simonneau, G., Galie, N., Rubin, L.J., Clinical classification of pulmonary hypertension (2004) J am Coll Cardiol, 43, pp. 5SS-12S; Galie, N., Hoeper, M.M., Humbert, M., Guidelines for the diagnosis and treatment of pulmonary hypertension (2009) Eur Heart J, 30, pp. 2493-2537; Galie, N., Humbert, M., Vachiery, J.L., 2015. ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension (2015) Eur Respir J, 46, pp. 903-975; Sitbon, O., Humbert, M., Nunes, H., Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: Prognostic factors and survival (2002) J am Coll Cardiol, 40, pp. 780-788; Miyamoto, S., Nagaya, N., Satoh, T., Clinical correlates and prognostic significance of six-minute walk test in patients with primary pulmonary hypertension. Comparison with cardiopulmonary exercise testing (2000) Am J Respir Crit Care Med, 161, pp. 487-492; Benza, R.L., Miller, D.P., Gomberg-Maitland, M., Predicting survival in pulmonary arterial hypertension: Insights from the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) (2010) Circulation, 122, pp. 164-172; Savarese, G., Paolillo, S., Costanzo, P., Do changes of 6-minute walk distance predict clinical events in patients with pulmonary arterial hypertension? A meta-analysis of 22 randomized trials (2012) J am Coll Cardiol, 60, pp. 1192-1201; Barst, R.J., Langleben, D., Frost, A., Sitaxsentan therapy for pulmonary arterial hypertension (2004) Am J Respir Crit Care Med, 169, pp. 441-447; Oudiz, R.J., Barst, R.J., Hansen, J.E., Cardiopulmonary exercise testing and six-minute walk correlations in pulmonary arterial hypertension (2006) Am J Cardiol, 97, pp. 123-126; Weatherald, J., Farina, S., Bruno, N., Cardiopulmonary exercise testing in pulmonary hypertension (2017) Ann am Thorac Soc, 14, pp. S84-S92; Paolillo, S., Farina, S., Bussotti, M., Exercise testing in the clinical management of patients affected by pulmonary arterial hypertension (2012) Eur J Prev Cardiol, 19, pp. 960-971; ATS statement: Guidelines for the six-minute walk test (2002) Am J Respir Crit Care Med, 166, pp. 111-117; Wensel, R., Opitz, C.F., Anker, S.D., Assessment of survival in patients with primary pulmonary hypertension: Importance of cardiopulmonary exercise testing (2002) Circulation, 106, pp. 319-324; Galie, N., Humbert, M., Vachiery, J.L., ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension (2015) Eur Heart J, 37, pp. 67-119; Sun, X.G., Hansen, J.E., Oudiz, R.J., Exercise pathophysiology in patients with primary pulmonary hypertension (2001) Circulation, 104, pp. 429-435; Groepenhoff, H., Westerhof, N., Jacobs, W., Exercise stroke volume and heart rate response differ in right and left heart failure (2010) Eur J Heart Fail, 12, pp. 716-720; Holverda, S., Gan, C.T., Marcus, J.T., Impaired stroke volume response to exercise in pulmonary arterial hypertension (2006) J am Coll Cardiol, 47, pp. 1732-1733; Lador, F., Bringard, A., Bengueddache, S., Kinetics of cardiac output at the onset of exercise in precapillary pulmonary hypertension Biomed Res Int 2016, , 2016; Farina, S., Teruzzi, G., Cattadori, G., Noninvasive cardiac output measurement by inert gas rebreathing in suspected pulmonary hypertension (2014) Am J Cardiol, 113, pp. 546-551; Wasserman, K., Hansen, J.E., Sue, D.Y., (1999) Principles of Exercise Testing and Interpretation, , 3rd Edn. Baltimore, Lippincott, Williams & Wilkins; Ferrazza, A.M., Martolini, D., Valli, G., Cardiopulmonary exercise testing in the functional and prognostic evaluation of patients with pulmonary diseases (2009) Respiration, 77, pp. 3-17; Robertson, H.T., Dead space: the physiology of wasted ventilation (2015) Eur Respir J, 45, pp. 1704-1716; Farina, S., Bruno, N., Agalbato, C., Physiological insights of exercise hyperventilation in arterial and chronic thromboembolic pulmonary hypertension (2018) Int J Cardiol, 259, pp. 178-182; Yasunobu, Y., Oudiz, R.J., Sun, X.G., End-tidal PCO2 abnormality and exercise limitation in patients with primary pulmonary hypertension (2005) Chest, 127, pp. 1637-1646; Jones, N.L., Robertson, D.G., Kane, J.W., Difference between end-tidal and arterial PCO2 in exercise (1979) J Appl Physiol, 47, pp. 954-960; Laveneziana, P., Garcia, G., Joureau, B., Dynamic respiratory mechanics and exertional dyspnoea in pulmonary arterial hypertension (2013) Eur Respir J, 41, pp. 578-587; Agostoni, P., Farina, S., Apostolo, A., Inside ventilatory regulation in pulmonary hypertension: Several hidden data are still undiscovered (2014) Eur J Prev Cardiol, 21, pp. 268-271; Velez-Roa, S., Ciarka, A., Najem, B., Increased sympathetic nerve activity in pulmonary artery hypertension (2004) Circulation, 110, pp. 1308-1312; Dempsey, J.A., Smith, C.A., Pathophysiology of human ventilatory control (2014) Eur Respir J, 44, pp. 495-512; Parati, G., Lombardi, C., Castagna, F., Heart failure and sleep disorders (2016) Nat Rev Cardiol, 13, pp. 389-403; Chang, A.J., Ortega, F.E., Riegler, J., Oxygen regulation of breathing through an olfactory receptor activated by lactate (2015) Nature, 527, pp. 240-244; Potus, F., Malenfant, S., Graydon, C., Impaired angiogenesis and peripheral muscle microcirculation loss contribute to exercise intolerance in pulmonary arterial hypertension (2014) Am J Respir Crit Care Med, 190, pp. 318-328; Ponikowski, P.P., Chua, T.P., Francis, D.P., Muscle ergoreceptor overactivity reflects deterioration in clinical status and cardiorespiratory reflex control in chronic heart failure (2001) Circulation, 104, pp. 2324-2330; McLaughlin, V.V., Archer, S.L., Badesch, D.B., ACCF/AHA 2009 expert consensus document on pulmonary hypertension (2009) Circulation, 119, pp. 2250-2294; Correale, M., Tricarico, L., Ferraretti, A., Cardiopulmonary exercise test predicts right heart catheterization (2017) Eur J Clin Invest, 47; Arena, R., Lavie, C.J., Milani, R.V., Cardiopulmonary exercise testing in patients with pulmonary arterial hypertension: An evidence-based review (2010) J Heart Lung Transplant, 29, pp. 159-173; Guazzi, M., Marenzi, G., Assanelli, E., Evaluation of the dead space/tidal volume ratio in patients with chronic congestive heart failure (1995) J Card Fail, 1, pp. 401-408; Dantzker, D.R., D’Alonzo, G.E., Bower, J.S., Pulmonary gas exchange during exercise in patients with chronic obliterative pulmonary hypertension (1984) Am Rev Respir Dis, 130, pp. 412-416; Zhao, Q.H., Wang, L., Pudasaini, B., Cardiopulmonary exercise testing improves diagnostic specificity in patients with echocardiography-suspected pulmonary hypertension (2017) Clin Cardiol, 40, pp. 95-101; Agostoni, P., Butler, J., Cardiac evaluation (1994) Textbook of Respiratory Medicine, pp. 943-962. , Murray JFE, Nadel JA, eds., Boston, Saunders Company; Sun, X.G., Hansen, J.E., Oudiz, R.J., Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension (2002) Circulation, 105, pp. 54-60; Sun, X.G., Hansen, J.E., Stringer, W.W., Oxygen uptake efficiency plateau: Physiology and reference values (2012) Eur J Appl Physiol, 112, pp. 919-928; Tan, X., Yang, W., Guo, J., Usefulness of decrease in oxygen uptake efficiency to identify gas exchange abnormality in patients with idiopathic pulmonary arterial hypertension (2014) Plos One, 9; Schwaiblmair, M., Faul, C., Von Scheidt, W., Ventilatory efficiency testing as prognostic value in patients with pulmonary hypertension (2012) BMC Pulm Med, 12, p. 23; Wensel, R., Francis, D.P., Meyer, F.J., Incremental prognostic value of cardiopulmonary exercise testing and resting haemodynamics in pulmonary arterial hypertension (2013) Int J Cardiol, 167, pp. 1193-1198; Diller, G.P., Dimopoulos, K., Okonko, D., Exercise intolerance in adult congenital heart disease: Comparative severity, correlates, and prognostic implication (2005) Circulation, 112, pp. 828-835; Deboeck, G., Scoditti, C., Huez, S., Exercise testing to predict outcome in idiopathic versus associated pulmonary arterial hypertension (2012) Eur Respir J, 40, pp. 1410-1419; Badagliacca, R., Papa, S., Valli, G., Echocardiography combined with cardiopulmonary exercise testing for the prediction of outcome in idiopathic pulmonary arterial hypertension (2016) Chest, 150, pp. 1313-1322; Groepenhoff, H., Vonk-Noordegraaf, A., Boonstra, A., Exercise testing to estimate survival in pulmonary hypertension (2008) Med Sci Sports Exerc, 40, pp. 1725-1732; Groepenhoff, H., Vonk-Noordegraaf, A., Van De Veerdonk, M.C., Prognostic relevance of changes in exercise test variables in pulmonary arterial hypertension (2013) Plos One, 8; Blumberg, F.C., Arzt, M., Lange, T., Impact of right ventricular reserve on exercise capacity and survival in patients with pulmonary hypertension (2013) Eur J Heart Fail, 15, pp. 771-775; Ferreira, E.V., Ota-Arakaki, J.S., Ramos, R.P., Optimizing the evaluation of excess exercise ventilation for prognosis assessment in pulmonary arterial hypertension (2014) Eur J Prev Cardiol, 21, pp. 1409-1419; Rausch, C.M., Taylor, A.L., Ross, H., Ventilatory efficiency slope correlates with functional capacity, outcomes, and disease severity in pediatric patients with pulmonary hypertension (2013) Int J Cardiol, 169, pp. 445-448; Oudiz, R.J., Midde, R., Hovenesyan, A., Usefulness of right-to-left shunting and poor exercise gas exchange for predicting prognosis in patients with pulmonary arterial hypertension (2010) Am J Cardiol, 105, pp. 1186-1191; Ramos, R.P., Arakaki, J.S., Barbosa, P., Heart rate recovery in pulmonary arterial hypertension: Relationship with exercise capacity and prognosis (2012) Am Heart J, 163, pp. 580-588
PY - 2018/5/2
Y1 - 2018/5/2
N2 - Despite recent advances in the therapeutic management of patients affected by pulmonary arterial hypertension (PAH), survival remains poor. Prompt identification of the disease, especially in subjects at increased risk of developing PAH, and prognostic stratification of patients are a necessary target of clinical practice but remain challenging. Cardiopulmonary exercise test (CPET) parameters, particularly peak oxygen uptake, end-tidal carbon dioxide tension and the minute ventilation/carbon dioxide production relationship, emerged as new prognostic tools for PAH patients. Moreover, CPET provides a comprehensive pathophysiological evaluation of patients’ exercise limitation and dyspnoea, which are the main and early symptoms of the disease. This review focuses on the role of CPET in the management of PAH patients, reporting guideline recommendations for CPET and discussing the pathophysiology of exercise limitation and the most recent use of CPET in the diagnosis, prognosis and therapeutic targeting of PAH. © ERS 2018.
AB - Despite recent advances in the therapeutic management of patients affected by pulmonary arterial hypertension (PAH), survival remains poor. Prompt identification of the disease, especially in subjects at increased risk of developing PAH, and prognostic stratification of patients are a necessary target of clinical practice but remain challenging. Cardiopulmonary exercise test (CPET) parameters, particularly peak oxygen uptake, end-tidal carbon dioxide tension and the minute ventilation/carbon dioxide production relationship, emerged as new prognostic tools for PAH patients. Moreover, CPET provides a comprehensive pathophysiological evaluation of patients’ exercise limitation and dyspnoea, which are the main and early symptoms of the disease. This review focuses on the role of CPET in the management of PAH patients, reporting guideline recommendations for CPET and discussing the pathophysiology of exercise limitation and the most recent use of CPET in the diagnosis, prognosis and therapeutic targeting of PAH. © ERS 2018.
KW - cardiopulmonary exercise test
KW - cardiovascular parameters
KW - drug targeting
KW - exercise
KW - human
KW - pathophysiology
KW - patient care
KW - practice guideline
KW - prognosis
KW - pulmonary hypertension
KW - respiratory tract parameters
KW - Review
KW - arterial pressure
KW - exercise test
KW - exercise tolerance
KW - lung
KW - predictive value
KW - pulmonary artery
KW - Arterial Pressure
KW - Exercise Test
KW - Exercise Tolerance
KW - Humans
KW - Hypertension, Pulmonary
KW - Lung
KW - Predictive Value of Tests
KW - Prognosis
KW - Pulmonary Artery
U2 - 10.1183/16000617.0134-2017
DO - 10.1183/16000617.0134-2017
M3 - Article
VL - 27
JO - European Respiratory Review
JF - European Respiratory Review
SN - 0905-9180
IS - 148
ER -