Abstract
| Original language | English |
|---|---|
| Journal | European Respiratory Review |
| Volume | 27 |
| Issue number | 148 |
| DOIs | |
| Publication status | Published - May 2 2018 |
Keywords
- cardiopulmonary exercise test
- cardiovascular parameters
- drug targeting
- exercise
- human
- pathophysiology
- patient care
- practice guideline
- prognosis
- pulmonary hypertension
- respiratory tract parameters
- Review
- arterial pressure
- exercise test
- exercise tolerance
- lung
- predictive value
- pulmonary artery
- Arterial Pressure
- Exercise Test
- Exercise Tolerance
- Humans
- Hypertension, Pulmonary
- Lung
- Predictive Value of Tests
- Prognosis
- Pulmonary Artery
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The role of cardiopulmonary exercise tests in pulmonary arterial hypertension. / Farina, S.; Correale, M.; Bruno, N.; Paolillo, S.; Salvioni, E.; Badagliacca, R.; Agostoni, P.; Cardiology, Right and Left Heart Failure Study Group of the Italian Society of.
In: European Respiratory Review, Vol. 27, No. 148, 02.05.2018.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - The role of cardiopulmonary exercise tests in pulmonary arterial hypertension
AU - Farina, S.
AU - Correale, M.
AU - Bruno, N.
AU - Paolillo, S.
AU - Salvioni, E.
AU - Badagliacca, R.
AU - Agostoni, P.
AU - Cardiology, Right and Left Heart Failure Study Group of the Italian Society of
N1 - Export Date: 25 January 2019 CODEN: EREWE Correspondence Address: Agostoni, P.; Dept of Cardiovascular Sciences, Centro Cardiologico Monzino, IRCCS, Via Parea 4, Italy; email: piergiuseppe.agostoni@ccfm.it References: Seeger, W., Adir, Y., Barbera, J.A., Pulmonary hypertension in chronic lung diseases (2013) J am Coll Cardiol, 62, pp. D109-D116; Hatano, S., Strasser, T., (1975) Primary Pulmonary Hypertension: Report on a WHO Meeting. Geneva, , http://apps.who.int/iris/bitstream/handle/10665/39094/9241560444_eng.pdf;jsessionid=4DEFB2B71BEDF5870191F1AE420B7EDF?sequence=1, World Health Organization; Barst, R.J., Rubin, L.J., Long, W.A., A comparison of continuous intravenous epoprostenol (Prostacyclin) with conventional therapy for primary pulmonary hypertension (1996) N Engl J Med, 334, pp. 296-301; Rubin, L.J., Mendoza, J., Hood, M., Treatment of primary pulmonary hypertension with continuous intravenous prostacyclin (Epoprostenol). 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PY - 2018/5/2
Y1 - 2018/5/2
N2 - Despite recent advances in the therapeutic management of patients affected by pulmonary arterial hypertension (PAH), survival remains poor. Prompt identification of the disease, especially in subjects at increased risk of developing PAH, and prognostic stratification of patients are a necessary target of clinical practice but remain challenging. Cardiopulmonary exercise test (CPET) parameters, particularly peak oxygen uptake, end-tidal carbon dioxide tension and the minute ventilation/carbon dioxide production relationship, emerged as new prognostic tools for PAH patients. Moreover, CPET provides a comprehensive pathophysiological evaluation of patients’ exercise limitation and dyspnoea, which are the main and early symptoms of the disease. This review focuses on the role of CPET in the management of PAH patients, reporting guideline recommendations for CPET and discussing the pathophysiology of exercise limitation and the most recent use of CPET in the diagnosis, prognosis and therapeutic targeting of PAH. © ERS 2018.
AB - Despite recent advances in the therapeutic management of patients affected by pulmonary arterial hypertension (PAH), survival remains poor. Prompt identification of the disease, especially in subjects at increased risk of developing PAH, and prognostic stratification of patients are a necessary target of clinical practice but remain challenging. Cardiopulmonary exercise test (CPET) parameters, particularly peak oxygen uptake, end-tidal carbon dioxide tension and the minute ventilation/carbon dioxide production relationship, emerged as new prognostic tools for PAH patients. Moreover, CPET provides a comprehensive pathophysiological evaluation of patients’ exercise limitation and dyspnoea, which are the main and early symptoms of the disease. This review focuses on the role of CPET in the management of PAH patients, reporting guideline recommendations for CPET and discussing the pathophysiology of exercise limitation and the most recent use of CPET in the diagnosis, prognosis and therapeutic targeting of PAH. © ERS 2018.
KW - cardiopulmonary exercise test
KW - cardiovascular parameters
KW - drug targeting
KW - exercise
KW - human
KW - pathophysiology
KW - patient care
KW - practice guideline
KW - prognosis
KW - pulmonary hypertension
KW - respiratory tract parameters
KW - Review
KW - arterial pressure
KW - exercise test
KW - exercise tolerance
KW - lung
KW - predictive value
KW - pulmonary artery
KW - Arterial Pressure
KW - Exercise Test
KW - Exercise Tolerance
KW - Humans
KW - Hypertension, Pulmonary
KW - Lung
KW - Predictive Value of Tests
KW - Prognosis
KW - Pulmonary Artery
U2 - 10.1183/16000617.0134-2017
DO - 10.1183/16000617.0134-2017
M3 - Article
VL - 27
JO - European Respiratory Review
JF - European Respiratory Review
SN - 0905-9180
IS - 148
ER -