The role of CD40 in ulcerative colitis: Histochemical analysis and clinical correlation

Lino Polese, Imerio Angriman, Attilio Cecchetto, Lorenzo Norberto, Marco Scarpa, Cesare Ruffolo, Michela Barollo, Antonio Sommariva, Davide F. D'Amico

Research output: Contribution to journalArticlepeer-review


Objectives: CD40 co-stimulator seems to be implicated in the loss of tolerance against self-antigens in many autoimmune diseases. The evidence suggests that in the pathogenesis of ulcerative colitis there is an activity state against self-antigens of the gut wall and flora. The aim of this study was to analyse the expression of CD40 in ulcerative colitis, comparing it with Crohn's disease and nonspecific inflammation of the colon and to determine whether there is a relationship between its expression and the activity stage of the disease. Methods: The expression of CD40 in the colonic samples of 51 patients (30 ulcerative colitis, 9 Crohn's disease and 12 nonspecific inflammation) was analysed by immunohistochemistry, Twenty-four patients with ulcerative colitis were scored according to clinical, endoscopic and histological classification. Results: The mean percentage of CD40+ cells per field in the colonic mucosa was: ulcerative colitis 21 ± 11%, Crohn's disease 24 ± 9%, nonspecific inflammation 7 ± 7%. The ulcerative colitis patients were statistically significantly different compared to the patients with nonspecific inflammation (P

Original languageEnglish
Pages (from-to)237-241
Number of pages5
JournalEuropean Journal of Gastroenterology and Hepatology
Issue number3
Publication statusPublished - 2002


  • Activity
  • CD40
  • Crohn's disease
  • Immunohistochemistry
  • Ulcerative colitis

ASJC Scopus subject areas

  • Gastroenterology

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