The role of CD40/CD40L and interferon regulatory factor 4 in Hodgkin lymphoma microenvironment

Donatella Aldinucci, Annunziata Gloghini, Antonio Pinto, Alfonso Colombatti, Antonino Carbone

Research output: Contribution to journalArticle

Abstract

Inflammation and cancer are two independent biological events that can play an interdependent role. The model of such interaction is represented by Hodgkin lymphoma (HL), where the microenvironment is dominated by an extensive mixed, potentially cellular inflammatory infiltrate that plays a decisive role in the pathobiology of HL. In this review we summarize updated information on the complex interactions between Hodgkin ReedSternberg (HRS) cells and their tissue microenvironment, highlighting the functional role of CD40/CD40L and interferon regulatory factor 4 (IRF4).

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalLeukemia and Lymphoma
Volume53
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • CD40
  • Classical Hodgkin lymphoma
  • IRF4
  • Tumor microenvironment

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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